p-Trifluoromethoxy phenol
- CAS NO.：828-27-3
- Empirical Formula: C7H5F3O2
- Molecular Weight: 178.11
- MDL number: MFCD00040988
- EINECS: 212-583-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:14:39
What is p-Trifluoromethoxy phenol?
Chemical properties
clear brown liquid
The Uses of p-Trifluoromethoxy phenol
Intermediates of Liquid Crystals
The Uses of p-Trifluoromethoxy phenol
4-(Trifluoromethoxy)phenol is used as a reactant in the preparation of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors.
The Uses of p-Trifluoromethoxy phenol
4-(Trifluoromethoxy)phenol was employed in the catalytic enantioselective synthesis of esters.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 25, p. 1097, 1982 DOI: 10.1021/jm00351a018
Properties of p-Trifluoromethoxy phenol
| Melting point: | 17-18°C |
| Boiling point: | 92 °C25 mm Hg(lit.) |
| Density | 1.375 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 187 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform, Methanol |
| form | Liquid |
| pka | 9.30±0.13(Predicted) |
| Specific Gravity | 1.375 |
| color | Clear brown |
| BRN | 1945934 |
| CAS DataBase Reference | 828-27-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Phenol, 4-(trifluoromethoxy)-(828-27-3) |
Safety information for p-Trifluoromethoxy phenol
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H314:Skin corrosion/irritation H412:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for p-Trifluoromethoxy phenol
| InChIKey | NWVVVBRKAWDGAB-UHFFFAOYSA-N |
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