OXIDIZED NIFEDIPINE
Synonym(s):2,6-Dimethyl-4-(2′-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester;Oxidized Nifedipine
- CAS NO.：67035-22-7
- Empirical Formula: C17H16N2O6
- Molecular Weight: 344.32
- MDL number: MFCD00153847
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-03 09:04:23
What is OXIDIZED NIFEDIPINE?
Description
Dehydro nifedipine is an active metabolite of nifedipine , a calcium channel blocker present in formulations used to treat hypertension and angina. Dehydro nifedipine is formed when nifedipine is metabolized by the cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5. Dehydro nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM.
Chemical properties
Pale Yellow Solid
The Uses of OXIDIZED NIFEDIPINE
Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons.
The Uses of OXIDIZED NIFEDIPINE
The main Nifedipine metabolite in human plasma
What are the applications of Application
Dehydro Nifedipine is a main Nifedipine metabolite in human plasma
Definition
ChEBI: Dehydronifedipine is a phenylpyridine.
Biochem/physiol Actions
CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.
Properties of OXIDIZED NIFEDIPINE
| Melting point: | 100-105 °C |
| Boiling point: | 443.7±45.0 °C(Predicted) |
| Density | 1.284±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 1.55±0.29(Predicted) |
| form | powder |
| color | yellow |
| EPA Substance Registry System | 3,5-Pyridinedicarboxylic acid, 2,6-dimethyl-4-(2-nitrophenyl)-,3,5-dimethyl ester (67035-22-7) |
Safety information for OXIDIZED NIFEDIPINE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for OXIDIZED NIFEDIPINE
OXIDIZED NIFEDIPINE manufacturer
Clickchem Research LLP
2Y
Phone:+91-8140031133
Whatsapp: +91- 8140031133
product: NIFEDIPINE EP IMPURITY A 90 % Above
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