Methyl 3-aminocrotonate
Synonym(s):Methyl 3-amino-2-butenoate
- CAS NO.：14205-39-1
- Empirical Formula: C5H9NO2
- Molecular Weight: 115.13
- MDL number: MFCD00071534
- EINECS: 238-056-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:15:51
What is Methyl 3-aminocrotonate?
Chemical properties
Crystals, yellowish-white
The Uses of Methyl 3-aminocrotonate
Methyl 3-aminocrotonate is used as intermediate for the syntheses of pharmaceuticals (e.g. 1,4-dihydropyridine derivatives) as well as for the manufacture of stabilizers and plastics. Product Data Sheet
The Uses of Methyl 3-aminocrotonate
Nitrendipine (N490150) metabolite. The pharmacokinetics of Nitrendipine was studied in the rat and 6 major metabolites were identified.
The Uses of Methyl 3-aminocrotonate
Methyl 3-aminocrotonate (Methyl 3-amino-2-butenoate) was used to synthesize 4-aryl-1,4-dihydropyridines possessing potential calcium channel blocking activity.
Preparation
3-Aminocrotonate Esters, e.g., methyl 3- aminocrotonate [14205-39-1] (3-amino-2-butenoic acid, methyl ester) can be prepared by treatment of acetoacetates with aqueous ammonia. They are mainly used in the production of a series of the dihydropyridine-type calcium antagonists.
General Description
Methyl 3-aminocrotonate undergoes waste-free solid-state cascade reaction with crystalline ninhydrin.
Flammability and Explosibility
Not classified
Properties of Methyl 3-aminocrotonate
| Melting point: | 81-83 °C(lit.) |
| Boiling point: | 112°C 42mm |
| Density | 1.1808 (rough estimate) |
| vapor pressure | 2.79-2.853hPa at 25℃ |
| refractive index | 1.4538 (estimate) |
| Flash point: | 91 °C |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | 18g/l |
| pka | 5.27±0.70(Predicted) |
| form | Crystalline Powder |
| color | White to slightly yellow |
| PH | 8-9 (18g/l, H2O, 20℃) |
| Water Solubility | insoluble |
| Sensitive | Hygroscopic |
| BRN | 956592 |
| CAS DataBase Reference | 14205-39-1(CAS DataBase Reference) |
| EPA Substance Registry System | 2-Butenoic acid, 3-amino-, methyl ester (14205-39-1) |
Safety information for Methyl 3-aminocrotonate
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H317:Sensitisation, Skin H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
Computed Descriptors for Methyl 3-aminocrotonate
| InChIKey | XKORCTIIRYKLLG-ONEGZZNKSA-N |
Methyl 3-aminocrotonate manufacturer
JSK Chemicals
3Y
Phone:+91-9879767984
Whatsapp: +91-9879767970
product: 14205-39-1 Methyl 3-aminocrotonate, 95% 99%
Kavya Pharma
Gujarat
Phone:91-7567426252
Whatsapp: 91-7567426252
product: Methyl 3 Aminocrotonate, 50kg
M. J. Chemicals
Maharashtra
Phone:91-9833004615
Whatsapp: 91-9833004615
product: Methyl 3-aminocrotonate
ASM Organics
Andhra Pradesh
Phone:91-9866122393
Whatsapp: 91-9866122393
product: Methyl 3-aminocrotonate
New Products
DL-beta-(3-Bromophenyl)alanine Tetrabutylammonium perchlorate N,O-Dimethylhydroxylamine hydrochloride (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid 2-Amino-5-bromo-4-(trifluoromethyl)pyridine（RM for Indian lab) N,N CARBONYL DIIMIDAZOLE Levothyroxine Impurity-F Montelukast EP Impurity-D/Montelukast USP Related Compound C Atorvastatin FXA Impurity/Atorvastatin Cyclic 6-Hydroxy Impurity Sodium Salt Isosulfan blue Keto N-Oxide Impurity Ivermectin Impurity F N-Nitroso des Methyl Tramadol/N-Nitroso-N-Desmethyl-Tramadol (R)-BoroLeu-(+)-Pinanediol-CF3COOH 1,4-bis(methylsulfonyl)butane 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 5-Methyl-1,3-benzenediacetonitrile 4-Fluorothiophenol 1-methyl amino-2,4-dinitro benzene CSA (DL-10-Camphorsulfonic Acid) 2-Hydroxy-4-methylnicotinic acid 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (2S)-1-((2S,3S)-3-(2-methylbutyl)-4-oxooxetan-2-yl)pentadecan-2-yl formylleucinate 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethane-1-sulfonyl chloride S-(1-(3,5-dichlorophenyl)-2,2,2-trifluoroethyl) ethanethioateRelated products of tetrahydrofuran
You may like
-
Methyl 3 amino crotonate 99%View Details -
Methyl 3-aminocrotonate 95.00% CAS 14205-39-1View Details
14205-39-1 -
Methyl 3-aminocrotonate CAS 14205-39-1View Details
14205-39-1 -
Methyl 3 Aminocrotonate, 50kgView Details
14205-39-1 -
Powder Methyl 3 Amino Crotonate, Purity: 99.0%, 14205-39-1View Details
14205-39-1 -
Methyl 3- Aminocrotonate Chemical PowderView Details
14205-39-1 -
Methyl 3-amino Crotonate, 25kgView Details
14205-39-1 -
Methyl 3-AminocrotonateView Details
14205-39-1
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.