ORPHENADRINE HYDROCHLORIDE

Chemical properties

White or almost white, crystalline powder.

The Uses of ORPHENADRINE HYDROCHLORIDE

Antihistaminic;H1 antogonist

Definition

ChEBI: A hydrochloride comprising equimolar amounts of ophenadrine and hydrogen chloride.

General Description

Odorless white or almost white crystalline powder. pH (aqueous solution) about 5.5. Bitter numbing taste.

Air & Water Reactions

May be sensitive to prolonged exposure to light and air. Water soluble.

Reactivity Profile

ORPHENADRINE HYDROCHLORIDE is incompatible with strong oxidizers.

Fire Hazard

Flash point data for ORPHENADRINE HYDROCHLORIDE are not available; however, ORPHENADRINE HYDROCHLORIDE is probably combustible.

Biochem/physiol Actions

Muscarinic receptor antagonist; H1 histamine receptor antagonist; muscle relaxant. Orphenadrine has also been reported to inhibit the noradrenergic transporter and to block the NMDA receptor ion channel.

Clinical Use

Anti-muscarinic:
Parkinsonism
Drug induced extra-pyramidal symptoms

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects: mydriasis @updlaryd ilation), hallucinations, distorted perceptions, pulse rate increase, intracranial pressure increase. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl

Metabolism

Orphenadrine is almost completely metabolised to at least 8 metabolites in the liver.
It is mainly excreted in the urine as metabolites and small amounts of unchanged drug