ORPHENADRINE HYDROCHLORIDE

Synonym(s):β-Dimethylaminoethyl 2-methylbenzhydryl ether hydrochloride;N,N-Dimethyl-2-(2-methylbenzhydryloxy)ethylamine hydrochloride;o-Methyldiphenhydramine hydrochloride

CAS NO.：341-69-5
Empirical Formula: C18H24ClNO
Molecular Weight: 305.84
MDL number: MFCD00012480
EINECS: 206-435-4
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-20 10:51:09

What is ORPHENADRINE HYDROCHLORIDE?

Chemical properties

White or almost white, crystalline powder.

The Uses of ORPHENADRINE HYDROCHLORIDE

Antihistaminic;H1 antogonist

Definition

ChEBI: A hydrochloride comprising equimolar amounts of ophenadrine and hydrogen chloride.

General Description

Odorless white or almost white crystalline powder. pH (aqueous solution) about 5.5. Bitter numbing taste.

Air & Water Reactions

May be sensitive to prolonged exposure to light and air. Water soluble.

Reactivity Profile

ORPHENADRINE HYDROCHLORIDE is incompatible with strong oxidizers.

Fire Hazard

Flash point data for ORPHENADRINE HYDROCHLORIDE are not available; however, ORPHENADRINE HYDROCHLORIDE is probably combustible.

Biochem/physiol Actions

Muscarinic receptor antagonist; H1 histamine receptor antagonist; muscle relaxant. Orphenadrine has also been reported to inhibit the noradrenergic transporter and to block the NMDA receptor ion channel.

Clinical Use

Anti-muscarinic:
Parkinsonism
Drug induced extra-pyramidal symptoms

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects: mydriasis @updlaryd ilation), hallucinations, distorted perceptions, pulse rate increase, intracranial pressure increase. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl

Metabolism

Orphenadrine is almost completely metabolised to at least 8 metabolites in the liver.
It is mainly excreted in the urine as metabolites and small amounts of unchanged drug

Properties of ORPHENADRINE HYDROCHLORIDE

Melting point:	159.0 to 164.0 °C
Boiling point:	-195 °C
Density	0.295 g/cm3
storage temp.	2-8°C
solubility	Freely soluble in water and in ethanol (96 per cent).
form	neat
color	Crystals
BRN	3745818
Stability:	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	341-69-5(CAS DataBase Reference)
EPA Substance Registry System	Orphenadrine hydrochloride (341-69-5)

Safety information for ORPHENADRINE HYDROCHLORIDE

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral
Precautionary Statement Codes	P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.