OROTIDINE

CAS NO.：314-50-1
Empirical Formula: C10H12N2O8
Molecular Weight: 288.21
MDL number: MFCD00057418
SAFETY DATA SHEET (SDS)
Update Date: 2025-04-17 18:22:24

What is OROTIDINE?

The Uses of OROTIDINE

Orotidine is a metabolite of Orotic Acid (O691500); a compound used in the preparation of therapeutic agents for chronic obstructive pulmonary disease (COPD) treatment.

What are the applications of Application

Orotidine is a nucleoside found naturally in fungi, bacteria and plants, and used as a reference in the research of disease and metabolic deficiencies.

Definition

ChEBI: A nucleoside formed by attaching orotic acid to a ribose ring via a beta1N(1)-glycosidic bond.

Enzyme inhibitor

This water-soluble ribonucleoside (FWfree-acid = 288.21 g/mol; CAS 314-50- 1; lmax of 267 nm in 0.1 N HCl (e = 9570 cm–1M–1; another report lists 9800) and 265 nm in 0.1 N methanolic NaOH (e = 8960 cm–1M–1; another report lists 7800)), first observed in Neurospora crassa, is also foound in the urine of cancer patients treated with 6-azauridine, Orotidine is most likely formed from OMP, its 5’-monophosphate ester and the direct precursor of UMP. Orotidine is readily hydrolyzed in dilute mineral acids. Target(s): orotate phosphoribosyltransferase; orotidine-5’-phosphate decarboxylase.

Properties of OROTIDINE

Melting point:	>400 °C
Density	1.847±0.06 g/cm3(Predicted)
storage temp.	−20°C
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
pka	2.62±0.20(Predicted)
color	White to Off-White