Orexin A (bovine, human, mouse, rat)

The Uses of Orexin A (bovine, human, mouse, rat)

appetite regulation, wakefulness, locomotor activity, hypothalamic-pituitary-adrenal activity, and pain thresholds. Orexin signaling is activated by nutrient depletion, causing an increase in food intake by delaying the signals of satiety. It activates the orexin-1 and -2 receptors with equal affinity.

General Description

Orexin is a hypothalamic neuropeptide consisting of 33 or 28 aa residues. Orexin has a pleiotropic function regulating feeding behavior, the sleep-wake cycle, metabolism, locomotor activity, and the endocrine system through orexin receptors. Orexin (also known as hypocretin) was discovered by reverse pharmacology as an endogenous ligand for two orphan GPCRs in 1998.

Biological Activity

orexin a, a 33 amino acid hypothalamic neuropeptide, is an endogenous agonist at orexin-1 and -2 receptors[1]. it play a role in appetite regulation, wakefulness, locomotor activity, hypothalamic-pituitary-adrenal activity, and pain thresholds[2].orexin a (10 and 30 mg/kg i.v., 5 min pre-plantar test) increases the latency to thermally stimulated paw contraction to baseline levels. orexin a (3-30 mg/kg; i.v.; 5 min pre-test) significantly increases the reaction latency of intravenous reactions of 10 and 30 mg/kg[3].[1]. rodgers r j, ishii y, halford j c g, et al. orexins and appetite regulation. neuropeptides, 2002, 36(5): 303-325 .[2]. lang m, söll r m, dürrenberger f, et al. structure-activity studies of orexin a and orexin b at the human orexin 1 and orexin 2 receptors led to orexin 2 receptor selective and orexin 1 receptor preferring ligands. journal of medicinal chemistry, 2004, 47(5): 1153-1160.[3]. bingham s, et al. orexin-a, an hypothalamic peptide with analgesic properties. pain, 2001, 92(1-2): 81-90.

Storage

-20°C