OPC 21268

Synonym(s):1-{1-[4(3-acetylaminopropoxy)benzoyl]-4-piperidyl}-3,4-dihydro-2(1H)-quinolinone hydrate;N-[3-[4-[[4-(3,4-dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-acetamide hydrate

CAS NO.：131631-89-5
Empirical Formula: C26H31N3O4
Molecular Weight: 449.54
MDL number: MFCD18632552
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 01:14:31

What is OPC 21268?

Description

OPC 21268 is a nonpeptide antagonist of vasopressin V₁ receptors (IC₅₀ = 0.4 μM in rat liver membranes). It is selective for V₁ over V₂ receptors (IC₅₀ = >100 μM in kidney membranes). It is also selective for rat over human V₁ receptors (K_is = 25 and 8,800 nM, respectively), which can be partially attributed to the alanine residue at position 337 of the rat sequence, instead of a glycine residue in the human sequence, with differences at positions 224, 310, and 324 also contributing. OPC 21268 (0.03-1 mg/kg, i.v.) inhibits pressor responses induced by arginine vasopressin (argipressin; ) in pithed rats and arginine vasopressin-induced vasoconstriction in conscious rats (ID₅₀ = 2 mg/kg). It induces hypotension in aged spontaneously hypertensive rats (SHRs) and stroke-prone SHRs when administered at a dose of 3 mg/kg.

The Uses of OPC 21268

OPC 21268 is a nonpeptide AVP (Vasopressin) Receptor V antagonist.

What are the applications of Application

OPC 21268 is a nonpeptide AVP (Vasopressin) Receptor V antagonist

Storage

Store at +4°C

Properties of OPC 21268

Boiling point:	772.5±60.0 °C(Predicted)
Density	1?+-.0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: ≥20mg/mL
pka	16.17±0.46(Predicted)
form	powder
color	white to off-white

Safety information for OPC 21268

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes	P273:Avoid release to the environment.

Computed Descriptors for OPC 21268

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