ONO-0300302

CAS NO.：856689-51-5
Empirical Formula: C29H35NO5
Molecular Weight: 477.59
Update Date: 2025-04-17 18:22:24

What is ONO-0300302?

Biological Activity

ONO-0300302 is an orally active and potent LPA1 (lysophosphatidic acid receptor 1) antagonist, with an IC50 of 0.086 μM. ONO-0300302 is a slow tight binding inhibitor, and its binding affinity increases with time, with Kd of 0.34 nM (37 °C, 2 h). ONO-0300302 can be used for benign prostatic hyperplasia (BPH) research[1]. ONO-0300302 shows moderate stability against rat microsomes[1]. ONO-0300302 inhibits significantly an LPA (lysophosphatidic acid receptor)-induced increase of intraurethral pressure (IUP) in rat (3 mg/kg, p.o.) and dog (1 mg/kg, p.o.) over 12 h[1].

References

[1]. Terakado M, et al. Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia. ACS Med Chem Lett. 2017 Nov 20;8(12):1281-1286.

Properties of ONO-0300302

Boiling point:	678.2±55.0 °C(Predicted)
Density	1.20±0.1 g/cm3(Predicted)
storage temp.	-20°C, protect from light
solubility	DMSO : 220 mg/mL (460.65 mM; Need ultrasonic)
form	Solid
pka	4.67±0.10(Predicted)
color	Off-white to light yellow

Safety information for ONO-0300302

Computed Descriptors for ONO-0300302

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