Octadecanedioic acid mono-tert-butyl ester
- CAS NO.：843666-40-0
- Empirical Formula: C22H42O4
- Molecular Weight: 370.57
- MDL number: MFCD09991735
- EINECS: 1592732-453-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-10-09 14:55:14
What is Octadecanedioic acid mono-tert-butyl ester?
Description
Octadecanedioic acid mono-tert-butyl ester is a non-cleavable ADC linker or alkyl chain-based PROTAC linker for the synthesis of antibody-drug couplings (ADCs) and PROTACs.
The Uses of Octadecanedioic acid mono-tert-butyl ester
18-(tert-Butoxy)-18-oxooctadecanoic Acid is used to engineer long-acting, potent exendin-4 based GLP-1 analog for microstructure-based transdermal delivery for glycemic control.
What are the applications of Application
18-(tert-Butoxy)-18-oxooctadecanoic acid) is a short linker featuring a carboxylic acid and a tert-butyl ester. Carboxylic acids can be reacted with alcohols or amines, while the tert-butyl ester can be deprotected and further connected to another molecule. It is a pharmaceutical intermediate ingredient used in the preparation of somatostatin. It also has catalytic activity.
Properties of Octadecanedioic acid mono-tert-butyl ester
| Melting point: | 68 °C |
| Boiling point: | 470.7±18.0 °C(Predicted) |
| Density | 0.950±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.78±0.10(Predicted) |
| color | White to Off-White |
Safety information for Octadecanedioic acid mono-tert-butyl ester
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P405:Store locked up. |
Computed Descriptors for Octadecanedioic acid mono-tert-butyl ester
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