O-(TERT-BUTYLDIMETHYLSILYL)HYDROXYLAMINE
Synonym(s):Aminoxy-tert-butyldimethylsilane
- CAS NO.：41879-39-4
- Empirical Formula: C6H17NOSi
- Molecular Weight: 147.29
- MDL number: MFCD00054944
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 06:31:32
What is O-(TERT-BUTYLDIMETHYLSILYL)HYDROXYLAMINE?
Physical properties
mp 62–65°C; bp 87–90°C/40 mmHg.
The Uses of O-(TERT-BUTYLDIMETHYLSILYL)HYDROXYLAMINE
O-(tert-Butyldimethylsilyl)hydroxylamine (tert-butyldimethylsilyl-O-hydroxylamine)is used to induce the cleavage, during solid supported synthesis of hydroxamic acids. It also finds it uses as a chemical additive and an intermediate.
The Uses of O-(TERT-BUTYLDIMETHYLSILYL)HYDROXYLAMINE
O-(tert-Butyldimethylsilyl)hydroxylamine (tert-butyldimethylsilyl-O-hydroxylamine) may be used to induce the cleavage, during solid supported synthesis of hydroxamic acids.
Preparation
the reagents are most conveniently prepared by treatment of hydroxylamine hydrochloride with ethylenediamine in dichloromethane, followed by the appropriate chlorosilane.A two-step procedure using ammonia in place of ethylenediamine has also been reported.
Properties of O-(TERT-BUTYLDIMETHYLSILYL)HYDROXYLAMINE
| Melting point: | 62-65 °C (lit.) |
| Boiling point: | 87-90 °C/40 mmHg (lit.) |
| Density | 0.849±0.06 g/cm3(Predicted) |
| Flash point: | 54°C |
| storage temp. | 2-8°C |
| solubility | freely sol hexane, chloroform, and most organic solvents;
insol water. |
| form | solid |
| pka | 4.75±0.70(Predicted) |
| Water Solubility | Hydrolyzes in water. |
| Sensitive | Moisture Sensitive |
| Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
| BRN | 2424306 |
| CAS DataBase Reference | 41879-39-4(CAS DataBase Reference) |
Safety information for O-(TERT-BUTYLDIMETHYLSILYL)HYDROXYLAMINE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for O-(TERT-BUTYLDIMETHYLSILYL)HYDROXYLAMINE
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