O-Benzylhydroxylamine hydrochloride
Synonym(s):Benzyloxyamine hydrochloride
- CAS NO.：2687-43-6
- Empirical Formula: C7H10ClNO
- Molecular Weight: 159.61
- MDL number: MFCD00012952
- EINECS: 220-249-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-16 08:03:12
What is O-Benzylhydroxylamine hydrochloride?
Chemical properties
white to light yellow crystal powde
The Uses of O-Benzylhydroxylamine hydrochloride
O-Benzylhydroxylamine hydrochloride is a reagent used for the synthesis of hydroxylamines and hydroxyamates.
The Uses of O-Benzylhydroxylamine hydrochloride
For use in the formation of nitrones from carbonyl compounds and their use in cycloaddition reactions. Used as a reagent used in the synthesis of hydroxylamines and hydroxyamates. Effective reagent used to prepare α-hydroxybenzylamines from α-hydroxyketones.
Synthesis
Add the O-benzylacetoxime to a mixed solution of 17 g of methanol and 200 g of a 38% mass concentration hydrochloric acid solution; react for 210 minutes at a temperature of 36°C and a stirring speed of 90 rpm; then distill under reduced pressure at a temperature of 65°C until a solid precipitate out, and cool to room temperature. The solid was washed with petroleum ether (100mL×3) and dried under vacuum at 80°C for 8 hours to obtain 95.18g of the target product O-Benzylhydroxylamine hydrochloride, with a purity of 99.87%; the yield is 98.72%.
Purification Methods
Recrystallise the hydrochloride from H2O or EtOH. [Beilstein 6 IV 2562.]
Properties of O-Benzylhydroxylamine hydrochloride
| Melting point: | 238 °C (subl.)(lit.) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Soluble in DMSO and methanol. |
| form | Crystalline Powder or Flakes |
| color | White to almost white |
| PH | 2.2～3.2 (10g/l, 25℃) |
| Sensitive | Hygroscopic |
| BRN | 3595440 |
| InChI | InChI=1S/C7H9NO.ClH/c8-9-6-7-4-2-1-3-5-7;/h1-5H,6,8H2;1H |
| CAS DataBase Reference | 2687-43-6(CAS DataBase Reference) |
Safety information for O-Benzylhydroxylamine hydrochloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H317:Sensitisation, Skin H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for O-Benzylhydroxylamine hydrochloride
| InChIKey | HYDZPXNVHXJHBG-UHFFFAOYSA-N |
| SMILES | C1(CON)=CC=CC=C1.Cl |
O-Benzylhydroxylamine hydrochloride manufacturer
Kavya Pharma
Gujarat
Phone:91-7567426252
Whatsapp: 91-7567426252
product: 2687-43-6 O Benzyl Hydroxylamine Hcl Powder, Grade: Analytical Grade, Purity: 99%
Bhakti Impex
Pune
Phone:91-9822268653
Whatsapp: 91-9822268653
product: O-benzylhydroxylamine hydrochloride
Mass Dye Chem Private Limited
Pune
product: O Benzyl Hydroxyl Amine Hydrochloride, CAS Number: 2687-43-6
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