NPPB
Synonym(s):5-Nitro-2-(3-phenylpropylamino)benzoic Acid - CAS 107254-86-4 - Calbiochem;NPPB;NPPB, CaCC Blocker II, Calcium-Activated, TMEM16 Blocker II, ANO Blocker II, Anoctamin Blocker II
- CAS NO.：107254-86-4
- Empirical Formula: C16H16N2O4
- Molecular Weight: 300.31
- MDL number: MFCD00153851
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-20 17:00:22
What is NPPB?
The Uses of NPPB
NPPB is a chloride channel blocker and acts as a GPR35 agonist. It maintains protonophoric activity and has been used to uncouple mitochondrial ATP synthesis in phagocytes.
The Uses of NPPB
Biochemical probe primarily as a Cl- channel blocker.
What are the applications of Application
5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB) is a Cox inhibitor and GPR35 activator
Definition
ChEBI: 5-Nitro-2-(3-phenylpropylamino)benzoic acid is a nitrobenzoic acid.
Biological Activity
Very potent chloride channel blocker.
Biochem/physiol Actions
Potent chloride channel blocker.
Storage
Store at RT
Properties of NPPB
| Melting point: | 178-180℃ |
| Boiling point: | 523.5±50.0 °C(Predicted) |
| Density | 1.323±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | ethanol: 3 mg/mL |
| form | Yellow solid |
| pka | 2.27±0.22(Predicted) |
| color | Light yellow to yellow |
Safety information for NPPB
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for NPPB
New Products
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