Nordihydroguaiaretic acid
Synonym(s):1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane;4,4′-(2,3-Dimethyltetramethylene)dipyrocatechol;Masoprocol;NDGA;Nordihydroguaiaretic Acid
- CAS NO.:500-38-9
- Empirical Formula: C18H22O4
- Molecular Weight: 302.36
- MDL number: MFCD00002206
- EINECS: 207-903-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-28 15:15:04
![Nordihydroguaiaretic acid Structural](https://img.chemicalbook.in/CAS/GIF/500-38-9.gif)
What is Nordihydroguaiaretic acid?
Description
Nordihydroguaiaretic acid (NDGA) is a grayish-white crystalline compound that was widely used as an antioxidant in animal fats in the 1950s and 1960s. It possesses phenolic properties similar to gallates, including their advantages and disadvantages. Besides the isolation of natural material (resinous exudate of creosote bush), NDGA has also been chemically synthesized. As the result of unfavorable toxicological findings, NDGA is prohibited from use in the US. More specifically, NDGA is a potent lipoxygenase inhibitor which interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carbox- ylesterase,and,to a lesser extent, cyclooxygenase.
The Uses of Nordihydroguaiaretic acid
Nordihydroguaiaretic acid is used in the treatment of multiple diseases, including cardiovascular diseases, neurological disorders and cancers. It is also used as an antioxidant.
What are the applications of Application
NDGA (Nordihydroguaiaretic acid) is an antioxidant and lipoxygenase inhibitor
Properties of Nordihydroguaiaretic acid
Melting point: | 184-186 °C (lit.) |
Boiling point: | 363.4°C (rough estimate) |
Density | 1.0772 (rough estimate) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Powder |
color | White to off-white |
Water Solubility | slightly soluble |
Safety information for Nordihydroguaiaretic acid
Signal word | Warning |
Pictogram(s) |
![]() Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Nordihydroguaiaretic acid
Abamectin manufacturer
CHROMOSYNTH PVT LTD
Myosynth Laboratories Pvt Ltd
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