N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride
Synonym(s):N,N,N′,N′-Tetramethyl-1,4-phenylenediammonium dichloride;TMPPD;Wurster’s reagent;Wurster-reagent, N,N,N′,N′-Tetramethyl-1,4-phenylene-diamine dihydrochloride
- CAS NO.：637-01-4
- Empirical Formula: C10H17ClN2
- Molecular Weight: 200.71
- MDL number: MFCD00012482
- EINECS: 211-274-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:25:26
What is N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride?
Chemical properties
Off white to gray powder
The Uses of N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride
N,N,N',N'-tetramethyl-p-phenylenediamine dihydrochloride (TMPD) is an oxidizable compound that serves as a reducing co-substrate for heme peroxidases. It is also used as a test reagent in microbiology for the classification of cytochrome oxidase positive aerobic microorganisms. It finds application as a detection of peroxidases on polyacrylamide gels.
The Uses of N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride
N,N,N′,N′-Tetramethyl-p-phenylenediamine dihydrochloride has been used to determine the oxidase activity displayed by various microorganisms.
What are the applications of Application
N,N,N′,N′-tetramethyl-p-phenylenediamine dihydrochloride is an oxidizable compound
General Description
N,N,N′,N′-Tetramethyl-p-phenylenediamine dihydrochloride (TMPD) is a redox mediator used in the oxidase test for detecting bacterial cytochrome c oxidases. TMPD is commonly used to perform the oxidase test for the colorimetric identification of pathogenic and non-pathogenic bacteria.
Purification Methods
Crystallise the salt from isopropyl or n-butyl alcohols, saturated with HCl. Treat it with aqueous NaOH to give the free base (see previous entry) which is filtered, dried and sublimed in a vacuum. [Guarr et al. J Am Chem Soc 107 5104 1985, Beilstein 13 H 74.]
Properties of N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride
| Melting point: | 222-224 °C(lit.) |
| Boiling point: | 378.54°C (rough estimate) |
| Density | 1.1961 (rough estimate) |
| refractive index | 1.6400 (estimate) |
| storage temp. | room temp |
| solubility | H2O: soluble500mg/10 mL |
| form | powder |
| color | off-white to gray |
| Water Solubility | SOLUBLE |
| Sensitive | Light Sensitive |
| BRN | 5132096 |
| Stability: | Stable. Incompatible with strong oxidizing agents, strong bases. |
| CAS DataBase Reference | 637-01-4(CAS DataBase Reference) |
| EPA Substance Registry System | 1,4-Benzenediamine, N,N,N',N'-tetramethyl-, dihydrochloride (637-01-4) |
Safety information for N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride
N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride manufacturer
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Mumbai
product: N,N,N,N-Tetramethyl-p-phenylenediamine Dihydrochloride (TMPPD) (CAS Number: 637-01-4)
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