N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate
Synonym(s):O-(N-Succinimidyl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate;HSTU
- CAS NO.：265651-18-1
- Empirical Formula: C9H16F6N3O3P
- Molecular Weight: 359.21
- MDL number: MFCD01863753
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 00:23:23
What is N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate?
Chemical properties
White to off-white crystalline powder
The Uses of N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate
Coupling reagent for peptide synthesis and the formation of other amides. Yield in aqueous solution is excellent too.
The Uses of N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate
Coupling reagent for peptide synthesis and the formation of other amides. Reactant for synthesis of liposomal contrast agents for magnetic resonance imaging, synthesis of protein labeling molecules, synthesis of thiol-reactive Cy5 derivatives.
What are the applications of Application
N,N,N′,N′-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate is a coupling reagent for peptide synthesis
General Description
N,N,N′,N′-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate can be used to prepare N-succinimidyl 4-[18F]fluorobenzoate ([18F]-SFB), a prosthetic group for the fluorination of biomolecules for PET imaging.
Properties of N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate
| Melting point: | 218-221°C |
| storage temp. | -20°C |
| solubility | Soluble in acetonitrile 0.5 g/mL. |
| form | Powder or Crystalline Powder |
| color | White to off-white |
| Sensitive | Moisture Sensitive |
| CAS DataBase Reference | 265651-18-1(CAS DataBase Reference) |
Safety information for N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate
| InChIKey | STWZCCVNXFLDDD-UHFFFAOYSA-N |
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