N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE
Synonym(s):Dimethylamidophosphoric dichloride;DMPADC
- CAS NO.：677-43-0
- Empirical Formula: C2H6Cl2NOP
- Molecular Weight: 161.95
- MDL number: MFCD00013896
- EINECS: 211-641-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 23:37:46
What is N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE?
Chemical properties
Light yellow liquid
The Uses of N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE
N,N-Dimethylphosphoramidodichloridate is used in the synthesis of phosphoramidates as well as (RS)-ethyl N,N-dimethylphosphoramidocyanidate (Nerve agent GA) which is used as a chemical weapon. It forms active intermediates, which react with alcohols in situ to give esters. It is also used to convert primary alcohols to alkyl chlorides. Furthe, it serves as an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. In addition to this, it reacts with 1,2 diols to prepare cyclic phosphoric amides followed by alkenes after reduction.
Properties of N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE
| Boiling point: | 77-79 °C/11 mmHg (lit.) |
| Density | 1.362 g/mL at 20 °C (lit.) |
| refractive index | n |
| Flash point: | 89-90°C/20mm |
| storage temp. | 2-8°C |
| solubility | Miscible with dimethoxyethane. |
| pka | -6.60±0.70(Predicted) |
| form | Oil to Semi-Solid |
| color | Colourless to Off-White |
| Sensitive | Moisture Sensitive |
| BRN | 969956 |
| Stability: | Hygroscopic, Moisture Sensitive |
| CAS DataBase Reference | 677-43-0 |
| EPA Substance Registry System | N,N-Dimethyl phosphoramidic dichloride (677-43-0) |
Safety information for N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for N,N-DIMETHYLPHOSPHORAMIDODICHLORIDATE
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