N,N-Dimethyloctylamine
Synonym(s):N,N-Dimethyloctylamine;DMOA;2-Hydroxy-1-(2-hydroxy-4-sulfo-1-naphthylazo)-3-naphthoic acid;Calconcarboxylic acid;Cal-Red
- CAS NO.：7378-99-6
- Empirical Formula: C10H23N
- Molecular Weight: 157.3
- MDL number: MFCD00009558
- EINECS: 230-939-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-06-05 18:44:30
What is N,N-Dimethyloctylamine?
Chemical properties
Liquid
The Uses of N,N-Dimethyloctylamine
Barlene(R) 8S is a tertiary amine used typically as an intermediate in the manufacture of quaternary ammonium compounds.
The Uses of N,N-Dimethyloctylamine
N,N-Dimethyl-n-octylamine is used as ion-pairing agent in the quantitative estimation of thiazinamium methylsulphate in a pharmaceutical preparation by HPLC. It acts as a counterion in mobile phase for separation of tetracycline, tetracycline analogs and their potential impurities by reversed-phase ion-pair chromatography. Further, it is used in the study of chiral separations by complexation with proteins in capillary zone electrophoresis. In addition to this, it is used as a mobile phase in direct resolution and quantitation of (R)- and (S)-disopyramide
Synthesis Reference(s)
Journal of the American Chemical Society, 72, p. 3073, 1950 DOI: 10.1021/ja01163a074
Tetrahedron Letters, 18, p. 1937, 1977
Properties of N,N-Dimethyloctylamine
| Melting point: | -57 °C (lit.) |
| Boiling point: | 195 °C (lit.) |
| Density | 0.765 g/mL at 25 °C (lit.) |
| vapor density | 5.4 (vs air) |
| vapor pressure | 0.8 mm Hg ( 25 °C) |
| refractive index | n |
| Flash point: | 149 °F |
| storage temp. | Store below +30°C. |
| form | Liquid |
| pka | 9.86±0.28(Predicted) |
| color | Clear |
| Water Solubility | slightly soluble |
| Sensitive | Air Sensitive |
| BRN | 1698081 |
| CAS DataBase Reference | 7378-99-6(CAS DataBase Reference) |
| NIST Chemistry Reference | N,N-Dimethyloctylamine(7378-99-6) |
| EPA Substance Registry System | N,N-Dimethyloctylamine (7378-99-6) |
Safety information for N,N-Dimethyloctylamine
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08  Environment GHS09 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H314:Skin corrosion/irritation H317:Sensitisation, Skin H330:Acute toxicity,inhalation H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N,N-Dimethyloctylamine
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