N,N-Dimethylbenzamide
- CAS NO.：611-74-5
- Empirical Formula: C9H11NO
- Molecular Weight: 149.19
- MDL number: MFCD00008320
- EINECS: 210-279-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-01-27 09:38:02
What is N,N-Dimethylbenzamide?
Chemical properties
white to slightly yellow cryst. low melting solid
The Uses of N,N-Dimethylbenzamide
Reagent for deoxygenation of secondary alcohols.
What are the applications of Application
N,N-Dimethylbenzamide is a reagent for secondary alcohol deoxygenation
Synthesis Reference(s)
The Journal of Organic Chemistry, 36, p. 2721, 1971 DOI: 10.1021/jo00817a036
Journal of the American Chemical Society, 77, p. 1114, 1955 DOI: 10.1021/ja01610a010
Synthetic Communications, 12, p. 989, 1982 DOI: 10.1080/00397918208061938
General Description
N,N-Dimethylbenzamide is a hydrotropic agent and its ability to solubilize drugs with low aqueous solubility has been investigated. It reacts with PhLnI complexes (Ln-Eu, Sm, Yb) to yield benzophenone in good yields. Deuterium exchange labelling experimets on N,N-dimethylbenzamide using [IrH2(Me2CO)2(PPh3)2]BF4 as catalyst and deuterium gas as the source of isotope has been conducted.
Properties of N,N-Dimethylbenzamide
| Melting point: | 43-45 °C (lit.) |
| Boiling point: | 132-133 °C/15 mmHg (lit.) |
| Density | 1.0753 (rough estimate) |
| refractive index | 1.5279 (estimate) |
| Flash point: | >230 °F |
| storage temp. | 2-8°C(protect from light) |
| pka | -1.14±0.70(Predicted) |
| form | powder to lump to clear liquid |
| color | White or Colorless to Light yellow |
| Water Solubility | Soluble in water. |
| BRN | 774955 |
| CAS DataBase Reference | 611-74-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzamide, N,N-dimethyl-(611-74-5) |
| EPA Substance Registry System | Benzamide, N,N-dimethyl- (611-74-5) |
Safety information for N,N-Dimethylbenzamide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N,N-Dimethylbenzamide
| InChIKey | IMNDHOCGZLYMRO-UHFFFAOYSA-N |
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