N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine
Synonym(s):Ishikawa’s Reagent
- CAS NO.：309-88-6
- Empirical Formula: C7H11F6N
- Molecular Weight: 223.16
- MDL number: MFCD00054683
- EINECS: 628-698-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:18
What is N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine?
Chemical properties
Clear colorless to yellow liquid
The Uses of N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine
Fluorinating agent.
The Uses of N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine
Reactant for:
- Friedel-Crafts type arylation of hydrofluorocarbons
- Microbial hydroxylation of antibiotics
- Electrochemical fluorination of trialkylamines and tetraalkylammonium salts
- Fluorination of pyrethroides
Reactant for synthesis of:
- γ-Hydroxy-α-fluoro-α-trifluoromethylcarboxamide
- Florfenicol and thiamphenicol
The Uses of N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine
Demonstrates utility in fluorination.7
What are the applications of Application
Ishikawa′s Reagent is An inserter of fluoro(trifluoromethyl) methylene moiety in unsaturated alcohols
General Description
GC analysis includes Et2NCF=CFCF3 (two isomers), both of which are active fluorinating agents.
Properties of N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine
| Boiling point: | 56-57 °C (lit.) |
| Density | 1.230 g/mL at 25 °C (lit.) |
| refractive index | 1.3460 |
| Flash point: | 56-57°C/58mm |
| storage temp. | Flammables area |
| solubility | soluble in Acetone,Ether |
| form | Liquid |
| pka | 1.50±0.70(Predicted) |
| Specific Gravity | 1.230 |
| color | Clear colorless to yellow |
| Merck | 14,5108 |
| CAS DataBase Reference | 309-88-6(CAS DataBase Reference) |
| EPA Substance Registry System | N,N-Diethyl-2H-perfluoropropanamine (309-88-6) |
Safety information for N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H226:Flammable liquids H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine
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![(-)-2-[METHYLAMINO]-1-PHENYLPROPANE](https://img.chemicalbook.in/CAS/GIF/33817-09-3.gif)
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