(-)-2-[Methylamino]-1-phenylpropane

Synonym(s):levo-Methamphetamine

CAS NO.：33817-09-3
Empirical Formula: C10H15N
Molecular Weight: 149.24
MDL number: MFCD00135973
EINECS: 251-687-0
SAFETY DATA SHEET (SDS)
Update Date: 2026-11-04 17:04:26

(-)-2-[Methylamino]-1-phenylpropane Structural

What is (-)-2-[Methylamino]-1-phenylpropane?

The Uses of (-)-2-[Methylamino]-1-phenylpropane

Nasal decongestant.

Indications

Used over-the-counter for nasal congestion.

Background

Levomethamphetamine, the L-enantiomer of methamphetamine is a sympathomimetic vasoconstrictor used in some over-the-counter (OTC) nasal decongestant inhalers in the United States.

Definition

ChEBI: Levmetamfetamine is a member of amphetamines.

Synthesis Reference(s)

The Journal of Organic Chemistry, 37, p. 2208, 1972 DOI: 10.1021/jo00978a034

General Description

R(-)-Methamphetamine, or levomethamphetamine, is a vasoconstrictor and component of multiple over-the-counter nasal decongestants. This certified Snap-N-Spike^? solution is suitable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications such as forensic analysis, sports testing, clinical toxicology, or urine drug testing. R(-)-Methamphetamine belongs to the amphetamine and phenethylamine classes of drugs.

Pharmacokinetics

Levomethamphetamine increases norepinephrine release resulting in increased vasocontriction.

Metabolism

Not Available

Properties of (-)-2-[Methylamino]-1-phenylpropane

Melting point:	38-40 °C
Boiling point:	104-107 °C(Press: 28 Torr)
Density	0.907±0.06 g/cm3(Predicted)
Flash point:	9℃
storage temp.	2-8°C
solubility	Chloroform (Slightly), Ethanol (Slightly), Methanol (Sparingly)
pka	pKa 9.99(H2O,t =25±0.5,I=0.01)(Approximate)
form	Oil
color	Pale Yellow

Safety information for (-)-2-[Methylamino]-1-phenylpropane

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H319:Serious eye damage/eye irritation H361:Reproductive toxicity
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P403+P233:Store in a well-ventilated place. Keep container tightly closed.