CYTOCHALASIN E

CAS NO.：36011-19-5
Empirical Formula: C28H33NO7
Molecular Weight: 495.56
MDL number: MFCD00005178
EINECS: 252-835-7
SAFETY DATA SHEET (SDS)
Update Date: 2025-08-20 16:56:16

What is CYTOCHALASIN E?

Description

The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin E is an epoxide-containing analog of cytochalasin B which potently and selectively inhibits the growth of endothelial cells (IC₅₀ < 1 nM), impairing angiogenesis and tumor growth. This cytochalasin does not inhibit glucose transport or HIV-1 protease activity.

Chemical properties

white powder

The Uses of CYTOCHALASIN E

Cytochalasin E is a fungal metabolite which has been shown to exhibit antimicrobial and antibacterial effects. Cytochalasin E is a microfilament inhibitor enhancing the low-affinity Fc epsilon receptor (CD23) expression.

The Uses of CYTOCHALASIN E

Cytochalasin E has been used as:

a toxin to study its effects on avocado plants
a component of the incubating medium in feline junctional adhesion molecule 1 (fJAM-1) expression assay
an inhibitor of actin polymerization to study its effects on mitochondria uptake by mice endothelial cells

The Uses of CYTOCHALASIN E

Cytochalasin E is one of a family of potent mycotoxins produced by a range of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, resulting in pronounced morphogenic changes in animals and plants. Despite the common mode of action, there is evidence that individual members display diverse selectivity. Specifically, cytochalasin E acts as an angiogenesis inhibitor and, unlike other cytochalasins, does not inhibit glucose transport.

Definition

ChEBI: A natural product found in Arthrinium sacchari.

What are the applications of Application

Cytochalasin E, Aspergillus clavatus is a fungal toxin used in actin polymerization and cytological research

Biochem/physiol Actions

Cytochalasin E is an epoxide that exhibits anti-proliferative activity in endothelial cells in vitro. It also participates in inhibiting tumor growth and angiogenesis in vivo. Cytochalasin E also possesses antimicrobial and antiviral properties.

Properties of CYTOCHALASIN E

Melting point:	206 °C
Boiling point:	587.59°C (rough estimate)
Density	1.2415 (rough estimate)
refractive index	1.6290 (estimate)
storage temp.	-20°C
solubility	DMF: 11 mg/ml; DMF:PBS (pH7.2) (1:30): 0.03 mg/ml; DMSO: 10 mg/ml; Ethanol: 2 mg/ml
form	White solid.
pka	11.22±0.70(Predicted)
color	White to off-white
BRN	1096975

Safety information for CYTOCHALASIN E

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H300:Acute toxicity,oral H310:Acute toxicity,dermal H330:Acute toxicity,inhalation H361:Reproductive toxicity
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P284:Wear respiratory protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P302+P350:IF ON SKIN: Gently wash with plenty of soap and water.