N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide
Synonym(s):N,N′-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide;N,N′-Bis(2,3-dihydroxypropyl)-5-nitroisophthalamide
- CAS NO.：76820-34-3
- Empirical Formula: C14H19N3O8
- Molecular Weight: 357.32
- MDL number: MFCD06657564
- EINECS: 616-392-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 01:08:06
What is N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide?
Description
N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide is a non-ionic organic compound that can be used as a reaction intermediate for the preparation of amidated iodinated x-ray contrast media. The amidation reaction is typically carried out in aqueous solution with an acid catalyst at room temperature for up to 24 hours. The amidation reaction condition and time can be optimized depending on the desired end product. Industrial preparation of iohexol typically involves the use of an x-ray generator and iopamidol, which is synthesized from diethylene triamine and ethylenediamine.
Chemical properties
White to Off-White Solid.
The Uses of N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide
N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide is used in the preparation of X-ray contrast agents.
Properties of N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide
| Melting point: | >140°C (dec.) |
| Density | 1.347 at 20℃ |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) |
| form | Solid |
| color | White to Off-White |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 76820-34-3(CAS DataBase Reference) |
Safety information for N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide
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