N,N'-bis-(2-Chloroethyl)urea
Synonym(s):1,3-Bis(2-chloroethyl)urea;BCU;NSC 36198
- CAS NO.：2214-72-4
- Empirical Formula: C5H10Cl2N2O
- Molecular Weight: 185.05
- MDL number: MFCD00068573
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-16 09:54:02
What is N,N'-bis-(2-Chloroethyl)urea?
The Uses of N,N'-bis-(2-Chloroethyl)urea
1,3-Bis(2-chloroethyl)urea is an impurity in the synthesis of Carmustine (C183875), an alkylating and carbamoylating nitrosourea compound. It interacts with DNA, RNA and proteins causing DNA interstrand cross linking which is cytotoxic and leads to apoptotic cell death.
Properties of N,N'-bis-(2-Chloroethyl)urea
| Melting point: | 128-129 °C |
| Boiling point: | 358.2±27.0 °C(Predicted) |
| Density | 1.245±0.06 g/cm3(Predicted) |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | neat |
| pka | 12.99±0.46(Predicted) |
| Stability: | Hygroscopic, Unstable in Solution |
Safety information for N,N'-bis-(2-Chloroethyl)urea
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N,N'-bis-(2-Chloroethyl)urea
| InChIKey | VBWBRZHAGLZNST-UHFFFAOYSA-N |
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![CARMUSTINE, [CHLOROETHYL-2-14C]-](https://img.chemicalbook.in/StructureFile/ChemBookStructure5/GIF/CB9104787.gif)
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