NIKKOMYCIN Z
- CAS NO.：59456-70-1
- Empirical Formula: C20H25N5O10
- Molecular Weight: 495.44
- MDL number: MFCD00869648
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-06-30 17:22:44
What is NIKKOMYCIN Z?
Description
Nucleoside-type antibiotic isolated from culture filtrates of Streptomyces tendae (19). Some analogs were also prepared by mutasynthesis, utilizing a uracil auxotroph of S. tendae.
The Uses of NIKKOMYCIN Z
Nikkomycins inhibit the growth of various plant pathogenic fungi but are inactive against bacteria and yeasts. Too susceptible to photodegradation by sunlight to be used in field application, and thus not developed commercially for agricultural use. Among the nikkomycins, nikkomycin Z is an orally active antifungal therapeutic agent for coccidioidomycosis. It is a competitive chitin synthase inhibitor that has been evaluated in mouse models for coccidioidomycosis.
Definition
ChEBI: A uridine-based nucleoside-peptide antibiotic which inhibits fungal chitin biosynthesis by inhibiting chitin synthase.
Pharmacology
By inhibiting chitin synthetase in fungi, nikkomycins inhibit cell wall synthesis, ultimately causing fungal cells to swell and burst.
Metabolism
There are no detailed reports on metabolism/transformation of nikkomycins in the environment.
Properties of NIKKOMYCIN Z
| Density | 1.646±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | H2O: soluble5mg/mL |
| pka | 2.70±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| Water Solubility | Water : ≥ 100 mg/mL (201.84 mM) |
Safety information for NIKKOMYCIN Z
Computed Descriptors for NIKKOMYCIN Z
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