nifurfoline
- CAS NO.：3363-58-4
- Empirical Formula: C13H15N5O6
- Molecular Weight: 337.29
- MDL number: MFCD00864944
- EINECS: 222-131-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:37
What is nifurfoline?
Originator
Furobactil,Carrion,France,1974
Definition
ChEBI: Nifurfoline is an imidazolidine-2,4-dione.
Manufacturing Process
20 g of nitrofurantoin are placed in 100 cc of dimethylformamide and the solution is heated to 75°C to 80°C. This temperature is maintained and 100 cc of 40% formaldehyde are added, followed by 10 g of freshly distilled morpholine. The heating is continued for one hour, the mixture cooled and filtered and the precipitate obtained is washed with 95% alcohol. 20 g of the desired product are obtained as yellow crystals which melt at 206°C.
Therapeutic Function
Antibacterial
Properties of nifurfoline
| Melting point: | 206°; also reported as mp 194-196° |
| Boiling point: | 486.5±55.0 °C(Predicted) |
| Density | 1.63±0.1 g/cm3(Predicted) |
| pka | 5.39±0.10(Predicted) |
Safety information for nifurfoline
Computed Descriptors for nifurfoline
New Products
6-Hydroxy-2,4-Diaminopyrimidine 2,6-Dipicolic Acid 3-AMINO-3-(2-CHLORO-PHENYL)-PROPIONIC ACID 4-Fluorophenylglycine 1-N-Boc-3-(aminoethyl)azetidine Dimedone 1-Boc-3-(cyanomethyl)azetidine N-BOC-piperidine-4-carboxylic acid 2-Amino-5-Bromo Pyridine 2-Amino-5-Iodopyridine 2,5-Dibromopyridine METHANOL-D1(OD) 3-BROMO PYRIDINE-D4 2-BROMOACETYL BROMIDE-D2 DEUTERIUM OXIDE FOR NMR BENZENE-D6 TOLUENE-D3 5-Acetylsalicylamide 1-(3-Chlorophenyl)-4-(3-Chloropropyl) piperazine hydrochloride 4-(Methyl amino)-3-Nitro benzoic acid 3,4,5-Trimethoxy benzoic acidRelated products of tetrahydrofuran
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