Nicotine ditartrate
Synonym(s):(?)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-bitartrate salt;(?)-Nicotine ditartrate;(?)-Nicotine hydrogen tartrate salt;(--)-Nicotine, Ditartrate - CAS 65-31-6 - Calbiochem;(S)-3-(1-Methyl-2-pyrrolindinyl)pyridine, Di- d-tartrate
- CAS NO.：65-31-6
- Empirical Formula: C18H26N2O12
- Molecular Weight: 462.41
- MDL number: MFCD00069368
- EINECS: 200-607-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:23:27
What is Nicotine ditartrate?
The Uses of Nicotine ditartrate
nicotinyl acetylchloline receptor agonist, ectoparasiticide
The Uses of Nicotine ditartrate
cathartic, laxative
What are the applications of Application
(?)-Nicotine ditartrate is a potent agonist of AChR
General Description
Potent agonist of the nicotinic acetylcholine receptor. Stimulates autonomic ganglia and skeletal muscle neuromuscular junctions.
Biological Activity
Nicotinic acetylcholine receptor (nAChR) agonist (K i values are 1, > 1000, 4000 and 7130 nM at α 4 β 2, α 1 β 1 δ γ , rat α 7 and human α 7 respectively). Exhibits vasoconstrictive, hypertensive and prothrombotic activity in vivo .
Biochem/physiol Actions
Product does not compete with ATP.
Safety Profile
Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and CO. See also NICOTINE.
Storage
Desiccate at RT
Properties of Nicotine ditartrate
| Melting point: | 90° |
| alpha | D20 +26° (c = 10) |
| storage temp. | Desiccate at RT |
| solubility | H2O: 50 mg/mL |
| form | powder |
| color | white to off-white |
| optical activity | [α]/D +20 to +26°, c = 1.0 in water |
| CAS DataBase Reference | 65-31-6(CAS DataBase Reference) |
| EPA Substance Registry System | Pyridine, 3-[(2S)-1-methyl-2-pyrrolidinyl]-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (65-31-6) |
Safety information for Nicotine ditartrate
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Environment GHS09 |
| GHS Hazard Statements |
H411:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P262:Do not get in eyes, on skin, or on clothing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Nicotine ditartrate
| InChIKey | RFEJUZJILGIRHQ-UHFFFAOYSA-N |
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