Nicosulfuron
Synonym(s):1-(4,6-Dimethoxy-2-pyrimidinyl)-3-[3-(dimethylcarbamoyl)-2-pyridylsulfonyl]urea;2-[(4,6-Dimethoxypyrimidin-2-ylcarbamoyl)sulfamoyl]-N,N-dimethylnicotinamide
- CAS NO.:111991-09-4
- Empirical Formula: C15H18N6O6S
- Molecular Weight: 410.4
- MDL number: MFCD00203303
- EINECS: 244-666-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-21 16:49:52
What is Nicosulfuron?
Chemical properties
White Solid
Chemical properties
White crystalline solid or powder. Phenolic odor.
The Uses of Nicosulfuron
Herbicide.
The Uses of Nicosulfuron
Post-emergence sulfonylurea herbicide
Definition
ChEBI: A N-sulfonylurea that is 2-(carbamoylsulfamoyl)-N,N-dimethylpyridine-3-carboxamide substituted by a 4,6-dimethoxypyrimidin-2-yl group at the amino nitrogen.
Agricultural Uses
Herbicide: Used as a post-emergence herbicide to control a variety of weeds on field corn and popcorn crops. Some formulations may be U.S. EPA restricted Use Pesticides (RUP). Approved for use in EU countries.
Trade name
ACCENT®; BASIS®; CELEBRITY®; CHALLENGER®; DASUL®; DPX 79406® Herbicide (with Rimsulfuron); DPX-V9636®; GHIBLI®; LAMA®; MATRIX® Herbicide (with Rimsulfuron); MILAGRO®; MISTRAL®; MOTIVEL®; NISSHIN®; SAMSON®; STEADFAST® (nicosulfuron + rimsulfuron)
Potential Exposure
Nicosulfuron is a sulfonylurea postemergence herbicide used to control a variety of weeds on field corn and popcorn crops. Some formulations may be registered as United States Restricted Use Pesticides (RUP)
Metabolic pathway
In the four systems investigated, the primary degradation pathway is to yield pyridine sulfonamide and 4,6-dimethoxy-2-aminopyrimidine. The plant and its microsomal system include the hydroxylation pathway at the 4-position of the pyrimidine ring, resulting in hydrolysis products by the cleavage of the sulfonylurea linkage. In mammals, contraction or rearrangement of the sulfonylurea linkage for nicosulfuron and N- demethylated nicosulfuron yields two unique products which have the N-pyridyl-N-pyrimidyl urea moiety and result in the uracil metabolite.
Shipping
UN3077 or UN3082 Environmentally hazardous substances, liquid or solid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.
Incompatibilities
Slowly hydrolyzes in water, releasing ammonia and forming acetate salts. Decomposed >165℃.
Waste Disposal
It is the responsibility of chemical waste generators to determine the toxicity and physical properties and of a discarded chemical and to properly identify its classification and certification as a hazardous waste and to determine the disposal method. United States Environmental Protection Agency guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult and follow all regional, national, state and local hazardous waste laws to ensure complete and accurate classification and disposal methods.
Properties of Nicosulfuron
| Melting point: | 141-144°C |
| Density | 1.4126 (rough estimate) |
| refractive index | 1.7000 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: 50 mg/mL (121.83 mM) |
| form | neat |
| pka | pKa (25°): 4.6 |
| form | Solid |
| color | White to off-white |
| Stability: | Hygroscopic, Unstable in DMSO |
| CAS DataBase Reference | 111991-09-4(CAS DataBase Reference) |
| EPA Substance Registry System | Nicosulfuron (111991-09-4) |
Safety information for Nicosulfuron
| Signal word | Warning |
| Pictogram(s) |
![]() Exclamation Mark Irritant GHS07 ![]() Environment GHS09 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Nicosulfuron
| InChIKey | RTCOGUMHFFWOJV-UHFFFAOYSA-N |
New Products
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