Ng-monomethyl-L-arginine acetate

Description

L-NMMA is the archetypal competitive NOS inhibitor to which other inhibitors are often compared. It is a relatively non-selective inhibitor of all NOS isoforms. The K_i values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 μM, respectively.

Chemical properties

White Crystalline Powder

The Uses of Ng-monomethyl-L-arginine acetate

A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells

The Uses of Ng-monomethyl-L-arginine acetate

Reagent to inhibit nitric oxide production in biological systems.

The Uses of Ng-monomethyl-L-arginine acetate

Nitric oxide synthase inhibitor

What are the applications of Application

L-NG-Monomethylarginine, Acetate Salt (L-NMMA) is an L-arginine analogue inhibitor of Ca2+-dependent NOS3 (endothelial NOS)

Biological Activity

Competitive, irreversible inhibitor of all three NOS isoforms.

Biochem/physiol Actions

NG-Methyl-L-arginine is an inhibitor of nitric oxide synthase in neurons, endothelial cells, and macrophages. It inhibits endothelium-derived relaxing factor and promotes contraction in pulmonary artery and vein. It stereo selectively inhibits the generation of nitric oxide (NO) from arginine. It promotes epinephrine and glucose levels, contributing to hyperglycemia in central nervous system.

Storage

Room temperature