NEP
- CAS NO.：2414276-32-5
- Empirical Formula: C29H31AsN4O5S2
- Molecular Weight: 654.63
- Update Date: 2025-04-18 09:52:24
What is NEP?
Biological Activity
NEP (VDP-green (NEP)) is an intramolecular charge transfer (ICT)-based sensing fluorescent probe for sensing orthodithiol-containing proteins (VDPs). NEP exhibits high selectivity for VDPs in living cells and animals, and displays a strong green fluorescence signal (λex/λem=430/535 nm). NEP has potential for Parkinson's research.
in vitro
NEP (1-30 μM; 6 hours) has no or little cytotoxicity in HepG2 and PC12 cells.
NEP (10 μM; 4 hours) causes the fluorescence intensity to decrease gradually in PC12 cells pretreated with 6-OHDA (0, 50, 100, and 200 μM; for 30 min).
NEP contains a dithiarsolane moiety (five-membered As-S ring) as the receptor of VDPs. In the presence of VDPs, NEP displays a strong green fluorescence signal produced by the cyclic dithiarsolane cleavage and subsequent intramolecular cyclization to liberate the fluorophore. NEP maintains a reliable fluorescence response within the range of pH 7-10.
in vivo
NEP (10 μM; for 4 h) causes the obvious green signal in zebrafishes (4 day old).
Properties of NEP
| pka | 11.42±0.20(Predicted) |
Safety information for NEP
Computed Descriptors for NEP
New Products
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