Nebivolol
- CAS NO.：99200-09-6
- Empirical Formula: C22H25F2NO4
- Molecular Weight: 405.43
- MDL number: MFCD00865796
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-01 21:34:22
What is Nebivolol?
Description
Nebilet was launched in Germany and the Netherlands as an antihypertensive agent. It is prepared by a five step route starting with 6-fluoro-4- oxobenzopyran-2-carboxylic acid. It is a selective β1-adrenergic receptor antagonist and is 50 times less potent at β2-receptors. Vasodialating properties occur via the nitric oxide pathway. While the L-isomer is more potent than the D-isomer, the racemic mixture is necessary for optimal activity. Upon administration, an immediate fall in blood pressure occurs, it improves both left ventricular systolic and diastolic function, and lowers peripheral blood resistance. Nebilet does not influence insulin sensitivity nor lipid profile comparible to atenolol. Doses of 50 mg of atenolol and 10 mg of Nebilet are equipotent but Nebilet has a longer duration of action due to an accumulation of the drug and increasing plasma levels of active metabolites.
Originator
Johnson & Johnson (US)
The Uses of Nebivolol
Labeled Nebivolol, intended for use as an internal standard for the quantification of Nebivolol by GC- or LC-mass spectrometry.
The Uses of Nebivolol
Nebivolol is a cardioselective beta-1 receptor blocking agent.
What are the applications of Application
Nebivolol is a cardioselective beta1 receptor blocking agent
Definition
ChEBI: A member of the class of chromanes that is 2,2'-iminodiethanol in which one hydrogen attached to each hydroxy-bearing carbon is replaced by a 6-fluorochroman-2-yl group.
brand name
Nebilet
Properties of Nebivolol
| Boiling point: | 600.5±55.0 °C(Predicted) |
| Density | 1.309±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| pka | 14.29±0.20(Predicted) |
| form | Solid |
| color | White to Off-White |
| CAS DataBase Reference | 99200-09-6(CAS DataBase Reference) |
Safety information for Nebivolol
Computed Descriptors for Nebivolol
| InChIKey | KOHIRBRYDXPAMZ-AWIIVWKDNA-N |
| SMILES | C([2H])([2H])([C@H](O)[C@@]1([H])CCC2C=C(C=CC=2O1)F)NC([2H])([2H])[C@H](O)[C@]1([H])CCC2C=C(C=CC=2O1)F |&1:3,5,21,23,r| |
New Products
Levothyroxine Impurity-F Montelukast EP Impurity-D/Montelukast USP Related Compound C Atorvastatin FXA Impurity/Atorvastatin Cyclic 6-Hydroxy Impurity Sodium Salt Isosulfan blue Keto N-Oxide Impurity Ivermectin Impurity F N-Nitroso des Methyl Tramadol/N-Nitroso-N-Desmethyl-Tramadol DL-beta-(3-Bromophenyl)alanine Tetrabutylammonium perchlorate N,O-Dimethylhydroxylamine hydrochloride (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid 2-Amino-5-bromo-4-(trifluoromethyl)pyridine（RM for Indian lab) N,N CARBONYL DIIMIDAZOLE (R)-BoroLeu-(+)-Pinanediol-CF3COOH 1,4-bis(methylsulfonyl)butane 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 5-Methyl-1,3-benzenediacetonitrile 4-Fluorothiophenol 1-methyl amino-2,4-dinitro benzene CSA (DL-10-Camphorsulfonic Acid) 2-Hydroxy-4-methylnicotinic acid 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (2S)-1-((2S,3S)-3-(2-methylbutyl)-4-oxooxetan-2-yl)pentadecan-2-yl formylleucinate 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethane-1-sulfonyl chloride S-(1-(3,5-dichlorophenyl)-2,2,2-trifluoroethyl) ethanethioateRelated products of tetrahydrofuran
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