NDI-010976

CAS NO.：1434635-54-7
Empirical Formula: C28H31N3O8S
Molecular Weight: 569.63
MDL number: MFCD28963986
Update Date: 2026-04-17 13:05:51

What is NDI-010976?

Description

ND-630 is an allosteric inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits ACC1 and ACC2 activity (IC₅₀s = 2.1 and 6.1 nM, respectively, for the human enzymes). It is selective for ACC over 101 enzymes, receptors, growth factors, transporters, and ion channels up to a concentration of 10 μM. ND-630 prevents dimerization of ACC by interacting within the phosphopeptide-acceptor and dimerization site. It reduces fatty acid synthesis (EC₅₀s = 66 and 9 nM in 10% FBS and serum-free media, respectively) and increases fatty acid oxidation in HepG2 cells. ND-630 reduces hepatic steatosis in a rat model of diet-induced obesity and in Zucker diabetic rats. It also improves insulin secretion stimulated by glucose and reduces hemoglobin A1c levels by 0.9% in Zucker diabetic rats.

The Uses of NDI-010976

Firsocostat or ND-630 (CAS# 1434635-54-7) is an inhibitor of acetyl-coA carboxylase and may favorably affect the morbidity and mortality associated with obesity, diabetes, and fatty liver disease from reduced hepatic steatosis, improved insulin sensitivity, and modulation of dyslipidemia.

Properties of NDI-010976

Boiling point:	779.0±70.0 °C(Predicted)
Density	1.42±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:75.0(Max Conc. mg/mL);131.66(Max Conc. mM) DMF:10.0(Max Conc. mg/mL);17.56(Max Conc. mM) Ethanol:3.0(Max Conc. mg/mL);5.27(Max Conc. mM)
form	A crystalline solid
pka	3.66±0.10(Predicted)
color	White to light yellow

Safety information for NDI-010976

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.