NAPHTHOL AS-E PHOSPHATE
Synonym(s):KG-501
- CAS NO.：18228-17-6
- Empirical Formula: C17H13ClNO5P
- Molecular Weight: 377.72
- MDL number: MFCD00042718
- EINECS: 242-106-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:27:10
What is NAPHTHOL AS-E PHOSPHATE?
Biological Activity
Naphthol AS-E phosphate is a CREB inhibitor that disrupts CREB-dependent transcription (Ki=10 μM) and CREB:CBP interaction (Ki=50 μM). It also disrupts the binding of phosphorylated CREB (Ser-133) to KIX with a Ki of approximately 90 μM.
in vitro
Naphthol AS-E phosphate inhibited (or partially inhibited) the induction of cAMP-related genes by preventing CREB:CBP interaction. KG-501 inhibited neurite outgrowth, synaptogenesis and reduced MAP2+ neurons.
in vivo
Naphthol AS-E phosphate inhibited the expression of CREB, CCL2 and ERK phosphorylation, while significantly reducing cAMP levels. CREB may help to fight neuroinflammation through the cAMP/ERKadjustment pathway, thereby protecting nerves.It significantly promoted neurological function in a mouse model treated with azomethane oxide (AOM), reducing ERK phosphorylation levels and cAMP concentrations in the cortex.
Properties of NAPHTHOL AS-E PHOSPHATE
| Density | 1.567±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | DMSO: soluble |
| form | A crystalline solid |
| pka | 1.04±0.30(Predicted) |
| color | White to light yellow |
| BRN | 6664478 |
Safety information for NAPHTHOL AS-E PHOSPHATE
Computed Descriptors for NAPHTHOL AS-E PHOSPHATE
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