N6-CYCLOHEXYLADENOSINE
Synonym(s):CHA
- CAS NO.：36396-99-3
- Empirical Formula: C16H23N5O4
- Molecular Weight: 349.39
- MDL number: MFCD00036808
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-04 10:33:10
What is N6-CYCLOHEXYLADENOSINE?
Description
N6-Cyclohexyladenosine is an adenosine receptor agonist. It selectively binds to adenosine A1 receptors in rat cortical membranes (IC50 = 2.3 nM) over A2 receptors in rat striatal membranes (IC50 = 870 nM). N6-Cyclohexyladenosine decreases heart rate and increases coronary flow in a perfused working rat heart model ex vivo (EC25s = 5 and 860 nM, respectively). In vivo, it decreases heart rate and blood pressure in normotensive rats (EC25s = 2.4 and 4.2 μg/kg, respectively). N6-Cyclohexyladenosine (100 μM) induces sleep in rats when administered via basal forebrain infusion. N6-Cyclohexyladenosine also decreases locomotor activity in mice (ED50 = 60 μg/kg, i.p.).
The Uses of N6-CYCLOHEXYLADENOSINE
N6-Cyclohexyladenosine is a derivative of Adenosine (A280400), and is used testing adenosine A1 and A2A receptor activation for pharmaceuticals such as antidepressants. N6-Cyclohexyladenosine also is used as a JAK2 inhibitor, blocking STAT3 signalling in human cancer cells.
What are the applications of Application
N6-Cyclohexyladenosine is a selective A1 adenosine receptor agonist
Biochem/physiol Actions
Selective A1 adenosine receptor agonist.
Storage
Store at -20°C
Properties of N6-CYCLOHEXYLADENOSINE
| Melting point: | 182 - 184°C |
| Boiling point: | 675.2±65.0 °C(Predicted) |
| Density | 1.71±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.12±0.70(Predicted) |
| color | White to Off-White |
| Stability: | Hygroscopic |
Safety information for N6-CYCLOHEXYLADENOSINE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N6-CYCLOHEXYLADENOSINE
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![CYCLOHEXYLADENOSINE, N6-[ADENINE-2,8-3H]-,N 6-CYCLOHEXYLADENOSINE-[2,8-3H]](https://img.chemicalbook.in/CAS/GIF/151362-69-5.gif)
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