N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine

Description

CZC-8004 (916603-07-1) is a pan-specific kinase inhibitor. May be coupled to sepharose via its amino-side chain for affinity chromatography applications1.

The Uses of N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine

A novel enzyme-interacting compounds using immobilized broad-spectrum ligands

The Uses of N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine

CZC-8004 is an aminopyrimidine that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES. It inhibits these kinases at low micromolar concentrations and can be immobilized to capture and purify these enzymes.

What are the applications of Application

N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine is A novel enzyme-interacting compound

Definition

ChEBI: CZC8004 is an aminopyrimidine and an organofluorine compound. It has a role as a protein kinase inhibitor.

References

1) Klutchko?et al. (1998),?2-Substituted aminopyrido[2,3-d]pyrilidin-7(8H)-ones, structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity; J. Med. Chem.,?41?3276