N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide
Synonym(s):N-(R)-(2-(Hydroxyaminocarbonyl)Methyl)-4-Methylpentanoyl-L-Naphthylalanyl-L-Alanine amide;N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine Amide, TNF-α Protease Inhibitor-0;TAPI-0 - CAS 143457-40-3 - Calbiochem;TNF-α Processing Inhibitor-0;TNF-α Protease Inhibitor-0
- CAS NO.：143457-40-3
- Empirical Formula: C24H32N4O5
- Molecular Weight: 456.53
- MDL number: MFCD02684279
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:51:59
![N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide Structural](https://img.chemicalbook.in/StructureFile/ChemBookStructure5/GIF/CB3299443.gif)
What is N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide?
The Uses of N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide
TAPI-0 is an inhibitor which blocks the maturation of cytokines, soluble cyokine receptors and other proteins that require the action of proteases.
What are the applications of Application
TAPI-0 is a hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC50 = 100 nM).
Properties of N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide
| Density | 1.227±0.06 g/cm3(Predicted) |
| pka | 9.17±0.20(Predicted) |
| form | White powder. |
Safety information for N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide
Computed Descriptors for N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide
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