N-METHYLISATIN

Synonym(s):N-Methylindoline-2,3-dione;NSC 42449

CAS NO.：2058-74-4
Empirical Formula: C9H7NO2
Molecular Weight: 161.16
MDL number: MFCD00005812
EINECS: 218-164-9
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is N-METHYLISATIN?

Chemical properties

ORANGE TO BROWNISH CRYSTALLINE POWDER

The Uses of N-METHYLISATIN

1-Methylisatin is used as a reactant for stereoselective preparation of spirobicyclic and bis-spirotricyclic pyrazolidinones, for regioselective preparation of spirocyclic oxindole-butenolides, for synthesis of spiro-oxindoles, for preparation of unsymmetrical oxindoles, for stereoselective preparation of hydroxyloxindoles via Morita-Baylis-Hillman reaction, for preparation of pyridinecarboxylic acid [(oxo)indolylidene)hydrazide derivatives (Schiff base hydrazides) as antibacterial agents.

The Uses of N-METHYLISATIN

Reactant for stereoselective preparation of spirobicyclic and bis-spirotricyclic pyrazolidinones
Reactant for regioselective preparation of spirocyclic oxindole-butenolides
Reactant for synthesis of spiro-oxindoles
Reactant for preparation of unsymmetrical oxindoles
Reactant for stereoselective preparation of hydroxyloxindoles via Morita-Baylis-Hillman reaction
Reactant for preparation of pyridinecarboxylic acid [(oxo)indolylidene)hydrazide derivatives (Schiff base hydrazides) as antibacterial agents

Synthesis Reference(s)

Journal of Medicinal Chemistry, 47, p. 2089, 2004 DOI: 10.1021/jm030483s

General Description

The interaction between 1-methylisatin and human adult haemoglobin was studied using the circular dichroism (CD) spectroscopic, anisotropy and FTIR investigations.

Properties of N-METHYLISATIN

Melting point:	130-133 °C (lit.)
Boiling point:	287.44°C (rough estimate)
Density	1.314
refractive index	1.5050 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
form	Crystalline Powder
pka	-2.41±0.20(Predicted)
color	Orange to brownish
Water Solubility	Insoluble in water.
λmax	427nm(CH2Cl2)(lit.)
BRN	128280
CAS DataBase Reference	2058-74-4(CAS DataBase Reference)

Safety information for N-METHYLISATIN

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water.