N-Methylisatin
Synonym(s):N-Methylindoline-2,3-dione;NSC 42449
- CAS NO.：2058-74-4
- Empirical Formula: C9H7NO2
- Molecular Weight: 161.16
- MDL number: MFCD00005812
- EINECS: 218-164-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:56:30
What is N-Methylisatin?
Chemical properties
ORANGE TO BROWNISH CRYSTALLINE POWDER
The Uses of N-Methylisatin
1-Methylisatin is used as a reactant for stereoselective preparation of spirobicyclic and bis-spirotricyclic pyrazolidinones, for regioselective preparation of spirocyclic oxindole-butenolides, for synthesis of spiro-oxindoles, for preparation of unsymmetrical oxindoles, for stereoselective preparation of hydroxyloxindoles via Morita-Baylis-Hillman reaction, for preparation of pyridinecarboxylic acid [(oxo)indolylidene)hydrazide derivatives (Schiff base hydrazides) as antibacterial agents.
The Uses of N-Methylisatin
- Reactant for stereoselective preparation of spirobicyclic and bis-spirotricyclic pyrazolidinones
- Reactant for regioselective preparation of spirocyclic oxindole-butenolides
- Reactant for synthesis of spiro-oxindoles
- Reactant for preparation of unsymmetrical oxindoles
- Reactant for stereoselective preparation of hydroxyloxindoles via Morita-Baylis-Hillman reaction
- Reactant for preparation of pyridinecarboxylic acid [(oxo)indolylidene)hydrazide derivatives (Schiff base hydrazides) as antibacterial agents
Synthesis Reference(s)
Journal of Medicinal Chemistry, 47, p. 2089, 2004 DOI: 10.1021/jm030483s
General Description
The interaction between 1-methylisatin and human adult haemoglobin was studied using the circular dichroism (CD) spectroscopic, anisotropy and FTIR investigations.
Properties of N-Methylisatin
| Melting point: | 130-133 °C (lit.) |
| Boiling point: | 287.44°C (rough estimate) |
| Density | 1.314 |
| refractive index | 1.5050 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | Crystalline Powder |
| pka | -2.41±0.20(Predicted) |
| color | Orange to brownish |
| Water Solubility | Insoluble in water. |
| λmax | 427nm(CH2Cl2)(lit.) |
| BRN | 128280 |
| CAS DataBase Reference | 2058-74-4(CAS DataBase Reference) |
Safety information for N-Methylisatin
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
Computed Descriptors for N-Methylisatin
N-Methylisatin manufacturer
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