1-Methylindole

Synonym(s):NSC 212534

CAS NO.：603-76-9
Empirical Formula: C9H9N
Molecular Weight: 131.17
MDL number: MFCD00005800
EINECS: 210-057-5
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-27 23:34:50

What is 1-Methylindole?

Chemical properties

deep yellow viscous liquid with a very unpleasant smell

The Uses of 1-Methylindole

1-Methylindole is useful for the determination of association constant for the electron-donor-acceptor complexes with 1-(2,4,6-trinitrophenyl) propan-2-one. It acts as a reactant for the preparation of polycyclic derivatives of indoles, bisindole derivatives and pharmaceutically active 2-oxo-1-pyrrolidine analogues. It is also used as a reactant for the preparation of Positron Emission Tomography (PET) imaging agents of protein kinase C (PKC) and glycogen synthase kinase-3 (GSK-3).

Synthesis Reference(s)

Synthetic Communications, 26, p. 1349, 1996 DOI: 10.1080/00397919608003495
Tetrahedron Letters, 27, p. 377, 1986 DOI: 10.1016/S0040-4039(00)84023-X

General Description

1-Methylindole undergoes Au(III)/TPPMS-catalyzed benzylation reaction with benzhydryl and benzylic alcohols.

Properties of 1-Methylindole

Melting point:	61.2°C (estimate)
Boiling point:	133 °C26 mm Hg(lit.)
Density	1.051 g/mL at 20 °C(lit.)
refractive index	n20/D 1.606(lit.)
Flash point:	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Soluble), DMSO (Slightly)
form	Liquid, May Develop Some Turbidity or Precipitate
color	Colorless to white
Water Solubility	insoluble
Sensitive	Light Sensitive
BRN	111026
Stability:	Light sensitive. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference	603-76-9(CAS DataBase Reference)
NIST Chemistry Reference	1H-Indole, 1-methyl-(603-76-9)
EPA Substance Registry System	1H-Indole, 1-methyl- (603-76-9)

Safety information for 1-Methylindole

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.