1-Methylindole
Synonym(s):NSC 212534
- CAS NO.：603-76-9
- Empirical Formula: C9H9N
- Molecular Weight: 131.17
- MDL number: MFCD00005800
- EINECS: 210-057-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-24 17:36:03
What is 1-Methylindole?
Chemical properties
deep yellow viscous liquid with a very unpleasant smell
The Uses of 1-Methylindole
1-Methylindole is useful for the determination of association constant for the electron-donor-acceptor complexes with 1-(2,4,6-trinitrophenyl) propan-2-one. It acts as a reactant for the preparation of polycyclic derivatives of indoles, bisindole derivatives and pharmaceutically active 2-oxo-1-pyrrolidine analogues. It is also used as a reactant for the preparation of Positron Emission Tomography (PET) imaging agents of protein kinase C (PKC) and glycogen synthase kinase-3 (GSK-3).
Synthesis Reference(s)
Synthetic Communications, 26, p. 1349, 1996 DOI: 10.1080/00397919608003495
Tetrahedron Letters, 27, p. 377, 1986 DOI: 10.1016/S0040-4039(00)84023-X
General Description
1-Methylindole undergoes Au(III)/TPPMS-catalyzed benzylation reaction with benzhydryl and benzylic alcohols.
Properties of 1-Methylindole
| Melting point: | 61.2°C (estimate) |
| Boiling point: | 133 °C26 mm Hg(lit.) |
| Density | 1.051 g/mL at 20 °C(lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Soluble), DMSO (Slightly) |
| form | Liquid, May Develop Some Turbidity or Precipitate |
| color | Colorless to white |
| Water Solubility | insoluble |
| Sensitive | Light Sensitive |
| BRN | 111026 |
| Stability: | Light sensitive. Combustible. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 603-76-9(CAS DataBase Reference) |
| NIST Chemistry Reference | 1H-Indole, 1-methyl-(603-76-9) |
| EPA Substance Registry System | 1H-Indole, 1-methyl- (603-76-9) |
Safety information for 1-Methylindole
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 1-Methylindole
| InChIKey | BLRHMMGNCXNXJL-UHFFFAOYSA-N |
1-Methylindole manufacturer
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