N-Methyl-D-aspartic acid
Synonym(s):(R)-2-(Methylamino)succinic acid;NMDA;N-Methyl-D-aspartic Acid, Hydrate - CAS 6384-92-5 - Calbiochem
- CAS NO.：6384-92-5
- Empirical Formula: C5H9NO4
- Molecular Weight: 147.13
- MDL number: MFCD00004226
- EINECS: 227-012-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:26:36
What is N-Methyl-D-aspartic acid?
Chemical properties
white to off-white crystalline powder
The Uses of N-Methyl-D-aspartic acid
NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
The Uses of N-Methyl-D-aspartic acid
NMDA agonist
What are the applications of Application
N-Methyl-D-Aspartic acid (NMDA) is a definitiveionotropic NMDA receptor agonist
Definition
ChEBI: An aspartic acid derivative having an N-methyl substituent and D-configuration.
General Description
N-Methyl-D-aspartic acid (NMDA) is an endogenously generated molecule in rat nervous system and endocrine glands. NMDA is present at low level (nmol/g) in the adenohypophysis, hypothalamus, brain, and testis. NMDA is derived from D-Asp by an S-adenosylmethionine-dependent enzyme also referred to as NMDA synthase.
Biological Activity
Prototypic NMDA receptor agonist. Also available as part of the Mixed NMDA Receptor Tocriset™ .
Biochem/physiol Actions
Excitotoxic amino acid. Prototypic agonist at the NMDA-type glutamate receptor that regulates ion channels; important in long-term potentiation, ischemia, and epilepsy.
Storage
Room temperature
References
[1] watkins jc, jane de. the glutamate story. br j pharmacol. 2006 jan;147 suppl 1:s100-8.
[2] lafon-cazal m, pietri s, culcasi m, bockaert j. nmda-dependent superoxide production and neurotoxicity. nature. 1993 aug 5;364(6437):535-7.
Properties of N-Methyl-D-aspartic acid
| Melting point: | 187-192 °C |
| Boiling point: | 267.21°C (rough estimate) |
| alpha | -28 º (c=1, HCl 6N) |
| Density | 1.4285 (rough estimate) |
| refractive index | -15 ° (C=2, H2O) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Aqueous Acid (Slightly), DMSO (Slightly), Water (Slightly) |
| form | solid |
| pka | 2.21±0.23(Predicted) |
| color | white |
| Water Solubility | slightly soluble |
| Sensitive | Hygroscopic |
| Merck | 14,6662 |
| BRN | 1724431 |
| CAS DataBase Reference | 6384-92-5(CAS DataBase Reference) |
Safety information for N-Methyl-D-aspartic acid
| Signal word | Danger |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08  Environment GHS09 |
| GHS Hazard Statements |
H319:Serious eye damage/eye irritation H372:Specific target organ toxicity, repeated exposure H400:Hazardous to the aquatic environment, acute hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N-Methyl-D-aspartic acid
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