N-Methyl-4-piperidinol
Synonym(s):1-Methyl-4-piperidinol;4-Hydroxy-1-methylpiperidine
- CAS NO.：106-52-5
- Empirical Formula: C6H13NO
- Molecular Weight: 115.17
- MDL number: MFCD00006500
- EINECS: 203-406-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:26:38
What is N-Methyl-4-piperidinol ?
Chemical properties
clear colorless to yellowish liquid after melting
The Uses of N-Methyl-4-piperidinol
Reactant for:• ;Optimization of Novobiocin scaffold to product antitumor agents1• ;Substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis2Reactant for synthesis of:• ;CaMKII inhibitors3• ;VEGFR and FGFR kinase inhibitors4• ;Phosphoinositide-3-kinase inhibitors5• ;Protein lysine methyltransferase G9a inhibitors6
The Uses of N-Methyl-4-piperidinol
4-Hydroxy-1-methylpiperidine is used as reactant for optimization of Novobiocin scaffold to product antitumor agents, substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis. It is also used as a reactant in the synthesis of CaMKII, VEGFR and FGFR kinase inhibitors and Phosphoinositide-3-kinase, Protein lysine methyltransferase G9a inhibitors.
Flammability and Explosibility
Not classified
Properties of N-Methyl-4-piperidinol
| Melting point: | 29-31 °C(lit.) |
| Boiling point: | 200 °C(lit.) |
| Density | 0.98 g/mL at 20 °C(lit.) |
| vapor pressure | 8.13-11Pa at 25℃ |
| refractive index | n |
| Flash point: | 190 °F |
| storage temp. | 2-8°C |
| form | Liquid After Melting |
| pka | 14.87±0.20(Predicted) |
| color | Clear colorless to brown |
| Water Solubility | MISCIBLE |
| Sensitive | Hygroscopic |
| BRN | 103024 |
| CAS DataBase Reference | 106-52-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Hydroxy-N-methylpiperidine(106-52-5) |
| EPA Substance Registry System | 4-Piperidinol, 1-methyl- (106-52-5) |
Safety information for N-Methyl-4-piperidinol
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
Computed Descriptors for N-Methyl-4-piperidinol
New Products
Cyclopropane-1,1-dicarboxylic acid Cefuroxime EP Impurity-A N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity tert-Butyl (2S)-[1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl]carbamate 4-amino-2-fluoro-N- methylbenzamide 5-Chloro-3- Methyl -1,3-2-benzoxazol-2(3H)-one N-(2-chloropyrimidin-4-yl)-N,2,3- trimethyl-2H- indazol 6-amine N-Boc-1,4-butanediamine 4-Bromo-2-fluoro-N-methylbenzamide valeronitrile 3-chlorobenzyl cyanide 3,4 Dimethoxy Benzylcyanide 3,4 Diethoxy Benzylcyanide 2-Chloro Benzylcyanide 3-Hydroxypropionitrile 5-azidovalericacid 6,6'-bis(difluoromethoxy)-2,2'-bis((3,4-dimethoxypyridin-2-yl)methylsulfinyl)-1H,1'H-5,5'-bibenzo[d]imidazole (1-((2'-(2-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol (1-((2'-(1-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol (4-Methoxyphenyl) hydrazine HydrochlorideRelated products of tetrahydrofuran
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