N-Methyl-2,2,2-trifluoroacetamide
- CAS NO.：815-06-5
- Empirical Formula: C3H4F3NO
- Molecular Weight: 127.07
- MDL number: MFCD00009670
- EINECS: 212-417-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:59:05
What is N-Methyl-2,2,2-trifluoroacetamide?
Chemical properties
WHITE CRYSTALS OR CRYSTALLINE POWDER
The Uses of N-Methyl-2,2,2-trifluoroacetamide
N-Methyltrifluoroacetamide is a useful synthetic intermediate. It is used to prepare electrophilic 11b-aryl derivs. of estradiol as steroidal affinity labels of the estrogen receptor a. It is also used to synthesize amino substituted derivatives of 5'-amino-5'-deoxy-5'-noraristeromycin as antiviral agent.
General Description
The high-resolution proton and fluorine resonance spectra of N-methyltrifluoroacetamide in tetrahydrofuran and acetone was studied.
Properties of N-Methyl-2,2,2-trifluoroacetamide
| Melting point: | 49-51 °C(lit.) |
| Boiling point: | 156-157 °C(lit.) |
| Density | 1.3215 (estimate) |
| Flash point: | 165 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to crystal |
| pka | 11.54±0.46(Predicted) |
| color | White to Almost white |
| Sensitive | Hygroscopic |
| BRN | 1703392 |
| InChI | InChI=1S/C3H4F3NO/c1-7-2(8)3(4,5)6/h1H3,(H,7,8) |
| CAS DataBase Reference | 815-06-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetamide, 2,2,2-trifluoro-N-methyl-(815-06-5) |
| EPA Substance Registry System | Acetamide, 2,2,2-trifluoro-N-methyl- (815-06-5) |
Safety information for N-Methyl-2,2,2-trifluoroacetamide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for N-Methyl-2,2,2-trifluoroacetamide
| InChIKey | IQNHBUQSOSYAJU-UHFFFAOYSA-N |
| SMILES | C(NC)(=O)C(F)(F)F |
New Products
Pentadecanoic acid 3-Bromophenylacetic acid 3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID Hendecanoic acid 2-Amino-5-cyanopyridine 2-Bromo-5-cyanopyridine 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile 3′-Hydroxyacetophenone 5-fluoro-1,3-benzodioxole 5-Bromo-4-chloro-3-indolyl-β-D-galactopyranoside Tetracaine Hydrochloride Ep Grade 2,2,2-Trichloroethyl chloroformate 2-Bromo-6-fluoroaniline 2-Amino-4-phenyl-thiazole 4-Chloro-2-methyl quinoline 2-(Chloromethyl) quinazolin-4(3H)-one 5-Phenyl-[1,3,4]-thiadiazol-2-amine 2-Chloro-6-nitro benzothiazole N-(4-Bromophenyl)-2-chloroacetamide 6-Isopropylpicolinonitrile N-Methyl-3,5-dinitro-2-pyridinamine Phenyl-boronic acid-d5 10,11-Dihdyro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide-d4 5-(2,4-difluorophenyl)oxazolidin-2-oneRelated products of tetrahydrofuran
You may like
-
N-Methyltrifluoroacetamide CAS 815-06-5View Details
815-06-5 -
N-Methyltrifluoroacetamide 95% CAS 815-06-5View Details
815-06-5 -
N-Methyltrifluoroacetamide CAS 815-06-5View Details
815-06-5 -
1503408-77-2 6-Chloro-3,4-dimethylpyridin-2-amine 97-99%View Details
1503408-77-2 -
665020-24-6 ethyl 1-(2,4-dichlorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxylate 97-99%View Details
665020-24-6 -
1187989-89-4 97-99%View Details
1187989-89-4 -
Methyl 1-(2,2,2-trifluoroethyl)azetidine-3-carboxylate 97-99%View Details
1872090-65-7 -
32659-49-7 97-99%View Details
32659-49-7
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.