N-Methyl-1H-Indole-5-EthaneSulphonamide
- CAS NO.：98623-50-8
- Empirical Formula: C11H14N2O2S
- Molecular Weight: 238.31
- EINECS: 1592732-453-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 17:22:31
What is N-Methyl-1H-Indole-5-EthaneSulphonamide?
The Uses of N-Methyl-1H-Indole-5-EthaneSulphonamide
N-Methyl-1H-indole-5-ethanesulfonamide is used as a reagent in the synthesis of Naratriptan Hydrochloride (N378730); a triptan drug used for the treatment of migraine headaches.
General Description
N-Methyl-1H-Indole-5-EthaneSulphonamide, also known as 2-(1H-Indol-5-yl)-N-methylethanesulfonamide, is a white solid.
Synthesis
At 40-45 ℃ (hydrogen pressure: 3-4 kg/cm2), 2-(3-Phenylsulf-anyl-1H-indol-5-yl)-ethanesulfonic acidmethylamide (14) (5 g, 0.014 mol) was hydrogenated in ethanol: water (7:3) (40 ml) in an autoclave for 10 h. After that, the reaction mass was cooled to room temperature, followed by removing the catalyst through filtering. The filtrate was distilled out to get N-Methyl-1H-Indole-5-EthaneSulphonamide. 
Properties of N-Methyl-1H-Indole-5-EthaneSulphonamide
| Melting point: | 124-125°C |
| Boiling point: | 458.4±47.0 °C(Predicted) |
| Density | 1.316±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 11.52±0.40(Predicted) |
| color | White to Off-White |
Safety information for N-Methyl-1H-Indole-5-EthaneSulphonamide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N-Methyl-1H-Indole-5-EthaneSulphonamide
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