N-LAUROYL-D-ERYTHRO-SPHINGOSINE

Chemical properties

white powder

The Uses of N-LAUROYL-D-ERYTHRO-SPHINGOSINE

Ceramide is one of the simplest sphingolipids, consisting of a sphingosine base N-linked to a fatty acid, and is a membrane mediator for cell-signaling events. N-Acyl chain length of membrane ceramides can influence bidimensional transitions, condensed domain morphology, and interfacial thickness.

The Uses of N-LAUROYL-D-ERYTHRO-SPHINGOSINE

C12 Ceramide (d18:1/12:0) or N-lauroyl-D-erythro-sphingosine has been used:

• as a lipid standard in the optimization of the liquid chromatography-mass spectrometry (LC-MS) method conditions
• as an internal standard for lipid extraction in U87MG (human glioma cell line)
• as an internal standard for the quantification of ceramide using liquid chromatography-mass spectrometry (LC-MS) in rat tissues

Definition

ChEBI: N-dodecanoylsphingosine is a N-acylsphingosine in which the ceramide N-acyl group is specified as dodecanoyl (lauroyl). It is functionally related to a dodecanoic acid.

General Description

Ceramide is a sphingolipid with long acyl chain attached to a fatty. It is synthesized in the endoplasmic reticulum by ceramide synthase.

Biochem/physiol Actions

Ceramides?are signaling sphingolipids, which are implicated in regulating stress responses and inflammation. It also regulates cell growth arrest, differentiation and apoptosis.