N-DESMETHYLCLOZAPINE

Chemical properties

Yellow Crystalline Solid

The Uses of N-DESMETHYLCLOZAPINE

N-Desmethylclozapine has been used as standard to quantify the clozapine plasma levels in treatment-refractory Chinese schizophrenic patients.

The Uses of N-DESMETHYLCLOZAPINE

A major metabolite of Clozapine. A potent and selective 5-HT2C serotonin receptor antogonist.

The Uses of N-DESMETHYLCLOZAPINE

A major metabolite of Clozapine (C587500). A potent and selective 5-HT2C serotonin receptor antogonist.

What are the applications of Application

N-Desmethylclozapine is a metabolite of clozapine and neurotransmitter

Definition

ChEBI: A dibenzodoazepine substituted with chloro and piperazino groups which is a major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.

General Description

N-Desmethylclozapine is an active metabolite of Clozapine, an atypical antipsychotic drug used for treatment of schizophrenia. Clozapine is sold under the trade names Clozaril^? and FrazaClo in the US. This Certified Snap-N-Spike^? Solution is suitable for use in urine drug testing, clinical toxicology, forensic analysis, and clinical monitoring by LC-MS/MS or GC/MS.

Biological Activity

A major metabolite of clozapine; a potent and selective 5-HT 2C serotonin receptor antagonist.

Biochem/physiol Actions

N-Desmethylclozapine serves as an agonist to muscarinic acetylcholine receptors, and is known to exert its antipsychotic action. It blocks synaptic transmission by antagonizing synaptic GABA (γ-aminobutyric acid) receptors.

Storage

Room temperature