N-desalkylflurazepam
Synonym(s):7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;Desalkylflurazepam;Norfludiazepam
- CAS NO.：2886-65-9
- Empirical Formula: C15H10ClFN2O
- Molecular Weight: 288.7
- MDL number: MFCD00083443
- EINECS: 220-748-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:19:34
What is N-desalkylflurazepam?
Description
Desalkylflurazepam (Item No. 18484) is an analytical reference material that is structurally categorized as a benzodiazepine. It is an active metabolite of several benzodiazepines, including flurazepam , flutoprazepam, fludiazepam, midazolam, and quazepam. Desalkylflurazepam inhibits L-type voltage-gated calcium channels (Cav; IC50s = 55 and 37 μM for Cav1.2 and 1.3, respectively) by positively modulating GABAA receptors. It can be detected in urine, serum, and meconium by LC-MS/MS. This product is intended for research and forensic applications.
Chemical properties
Light Yellow Solid
The Uses of N-desalkylflurazepam
The major human metabolite of flurazepam. This is a controlled drug precursor therefore a liscence may be required for purchase
Definition
ChEBI: Desalkylflurazepam is a benzodiazepine.
General Description
N-Desalkylflurazepam (also known as norflurazepam, 2886-65-9) is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward.
Mode of action
N-Desalkylflurazepam is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward.
Properties of N-desalkylflurazepam
| Melting point: | 204-206°C |
| Boiling point: | 454.0±45.0 °C(Predicted) |
| Density | 1.39±0.1 g/cm3(Predicted) |
| Flash point: | 9℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 11.55±0.70(Predicted) |
| form | A neat solid |
| color | White to off-white |
| InChI | InChI=1S/C15H10ClFN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20) |
| CAS DataBase Reference | 2886-65-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Norfludiazepam(2886-65-9) |
Safety information for N-desalkylflurazepam
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H336:Specific target organ toxicity,single exposure; Narcotic effects |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..… |
Computed Descriptors for N-desalkylflurazepam
| InChIKey | UVCOILFBWYKHHB-UHFFFAOYSA-N |
| SMILES | N1C2=CC=C(Cl)C=C2C(C2=CC=CC=C2F)=NCC1=O |
N-desalkylflurazepam manufacturer
GLP Pharma Standards
Clickchem Research LLP
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