3-Cyclohexylaminopropanesulfonic Acid

Synonym(s):Caps;3-(Cyclohexylamino)-1-propanesulfonic acid;Accessories;Pipettes;Piston-operated pipettes

CAS NO.：1135-40-6
Empirical Formula: C9H19NO3S
Molecular Weight: 221.32
MDL number: MFCD00003837
EINECS: 214-492-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-06-24 18:42:22

3-Cyclohexylaminopropanesulfonic Acid Structural

What is 3-Cyclohexylaminopropanesulfonic Acid?

Chemical properties

White/clear crystalline powder

The Uses of 3-Cyclohexylaminopropanesulfonic Acid

CAPS (N-cyclohexyl-3-aminopropanesulfonic acid) buffer salt is used to formulate CAPS buffer, a zwitterionic buffer that is useful in the range of pH 7.9-11.1. CAPS buffer is widely used in Western and immunoblotting experiments as well as protein sequencing and identification. Used in the electrotransfer of proteins to PVDF (sc-3723) or nitrocellulose membranes (sc-3718,?sc-3724). The high pH of this buffer makes it useful for the transfer of proteins with a pI > 8.5. CAPS is not one of the original Good?s buffers, although it has a similar structure to the other propanesulfonic acids and was selected as a highly water soluble buffering reagent with an optimum buffering pH of 10.4 and minimal reactivity with enzymes or proteins, minimal salt effects.

The Uses of 3-Cyclohexylaminopropanesulfonic Acid

3-Cyclohexylaminopropanesulfonic Acid buffer salt is used to formulate CAPS buffer, a zwitterionic buffer that is useful in the range of pH 7.9-11.1. CAPS buffer is widely used in Western and immunoblotting experiments as well as protein sequencing and identification. Used in the electrotransfer of proteins to PVDF (sc-3723) or nitrocellulose membranes (sc-3718, sc-3724). The high pH of this buffer makes it useful for the transfer of proteins with a pI > 8.5. CAPS is not one of the original Good's buffers, although it has a similar structure to the other propanesulfonic acids and was selected as a highly water soluble buffering reagent with an optimum buffering pH of 10.4 and minimal reactivity with enzymes or proteins, minimal salt effects. It is a biological buffer.

What are the applications of Application

CAPS is used to formulate CAPS buffer, a zwitterionic buffer useful in the range of pH 7.9-11.1

Definition

ChEBI: Cyclohexylaminopropanesulfonic acid is an amine.

Flammability and Explosibility

Not classified

Properties of 3-Cyclohexylaminopropanesulfonic Acid

Melting point:	>300 °C(lit.)
Density	1.1809 (rough estimate)
vapor pressure	0Pa at 25℃
refractive index	1.5250 (estimate)
Flash point:	>110℃
storage temp.	room temp
solubility	H₂O: 0.5 M at 20 °C, clear
form	Powder/Solid
color	White
PH	3.0-7.0 (20℃, 0.5M in H2O)
pka	10.4(at 25℃)
Odor	Odorless
PH Range	3 - 7
Water Solubility	9 g/100 mL (20 ºC)
λmax	λ: 260 nm Amax: ≤0.04 λ: 280 nm Amax: ≤0.04
Merck	14,1767
BRN	2835588
Stability:	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	1135-40-6(CAS DataBase Reference)
EPA Substance Registry System	1-Propanesulfonic acid, 3-(cyclohexylamino)- (1135-40-6)

Safety information for 3-Cyclohexylaminopropanesulfonic Acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.