N-Boc-PEG6-alcohol

CAS NO.：331242-61-6
Empirical Formula: C17H35NO8
Molecular Weight: 381.46
MDL number: MFCD28385472
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 04:28:17

What is N-Boc-PEG6-alcohol?

Description

N-Boc-PEG6-alcohol is a PEG linker containing a Boc protected amine group and a terminal hydroxyl group. The Boc protecting group can be removed under acidic conditions. The hydroxyl group can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound.

The Uses of N-Boc-PEG6-alcohol

N-Boc-PEG6-alcohol is a PROTAC bridge that belongs to the PEG class and the Alkyl/ether class. N-Boc-PEG6-alcohol can be used to synthesize a series of PROTAC molecules from Chemicalbook. N-Boc-PEG6-alcohol is a cleavable ADC bridge for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaandforanE3ubiquitinligaseandtheotherisforthetargetprotein.PROTACsexploittheintracelChemicalbooklularubiquitin-proteasomesystemtoselectivelydegradetargetproteins.ADCsarecomprisedofanantibodytowhichisattachedanADCcytotoxinthroughanADClinker.

Properties of N-Boc-PEG6-alcohol

Boiling point:	487.1±45.0 °C(Predicted)
Density	1.087±0.06 g/cm3(Predicted)
solubility	Soluble in DMSO, DCM, DMF
pka	12.23±0.46(Predicted)
form	Viscous Liquid
color	Colorless to light yellow

Safety information for N-Boc-PEG6-alcohol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection.