N-Boc-PEG6-alcohol
- CAS NO.：331242-61-6
- Empirical Formula: C17H35NO8
- Molecular Weight: 381.46
- MDL number: MFCD28385472
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-21 10:31:43
What is N-Boc-PEG6-alcohol?
Description
N-Boc-PEG6-alcohol is a PEG linker containing a Boc protected amine group and a terminal hydroxyl group. The Boc protecting group can be removed under acidic conditions. The hydroxyl group can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound.
The Uses of N-Boc-PEG6-alcohol
N-Boc-PEG6-alcohol is a PROTAC bridge that belongs to the PEG class and the Alkyl/ether class. N-Boc-PEG6-alcohol can be used to synthesize a series of PROTAC molecules from Chemicalbook. N-Boc-PEG6-alcohol is a cleavable ADC bridge for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaandforanE3ubiquitinligaseandtheotherisforthetargetprotein.PROTACsexploittheintracelChemicalbooklularubiquitin-proteasomesystemtoselectivelydegradetargetproteins.ADCsarecomprisedofanantibodytowhichisattachedanADCcytotoxinthroughanADClinker.
Properties of N-Boc-PEG6-alcohol
| Boiling point: | 487.1±45.0 °C(Predicted) |
| Density | 1.087±0.06 g/cm3(Predicted) |
| solubility | Soluble in DMSO, DCM, DMF |
| pka | 12.23±0.46(Predicted) |
| form | Viscous Liquid |
| color | Colorless to light yellow |
Safety information for N-Boc-PEG6-alcohol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for N-Boc-PEG6-alcohol
New Products
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