N-acetyl aspartyl-glutaMic acid

Synonym(s):NAAG;NAAG - CAS 3106-85-2 - Calbiochem;N-Acetyl-Asp-Glu, N-acetylaspartylglutamate;Spaglumic acid;Spaglumic acid

CAS NO.：3106-85-2
Empirical Formula: C11H16N2O8
Molecular Weight: 304.25
MDL number: MFCD00076652
EINECS: 628-471-3
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-22 18:57:36

N-acetyl aspartyl-glutaMic acid Structural

What is N-acetyl aspartyl-glutaMic acid?

Chemical properties

White powder

The Uses of N-acetyl aspartyl-glutaMic acid

N-acetyl aspartyl-glutamic acid is a spaglumic acid is a marker of neuronal integrity and was used in the detection of therapeutic values of antidrepressant treatments.

The Uses of N-acetyl aspartyl-glutaMic acid

N-Acetyl-Asp-Glu has been used in N-acetylated α-linked acidic dipeptidase (NAALADase) assay and affinity experiments.

What are the applications of Application

N-Acetyl-Asp-Glu-OH is an endogenous neurotransmitter with high affinity for mGluR-3

Definition

ChEBI: A dipeptide composed of N-acetyl-L-aspartic acid and L-glutamic acid joined by a peptide linkage.

General Description

NAAG is a neuropeptide and a neurotransmitter that is abundant in the mammalian nervous system. It remains uncertain whether this compound activates NMDA receptors; however, it is clearly demonstrated to act as a selective agonist of mGluR3, both in vitro and in vivo.

Biochem/physiol Actions

Endogenous neurotransmitter localized to neurons with high affinity for metabotropic glutamate receptors, mGluR3. It is an antagonist at NMDA receptors. Catabolized by carboxypeptidase II, which is expressed on astrocyte membranes, to N-acetylaspartate and glutamate.

Storage

-20°C

Properties of N-acetyl aspartyl-glutaMic acid

Melting point:	171-173 °C
Boiling point:	769.5±60.0 °C(Predicted)
Density	1.472±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	H₂O: 50 mg/mL
form	powder
pka	3.04±0.10(Predicted)
color	white
optical activity	[α]22/D 34.5°, c = 1.1 in H2O(lit.)
Water Solubility	Soluble to 100 mM in water
Stability:	Hygroscopic

Safety information for N-acetyl aspartyl-glutaMic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.