N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
- CAS NO.：381168-77-0
- Empirical Formula: C19H12F2N4
- Molecular Weight: 334.32
- Update Date: 2025-12-16 16:15:04
What is N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine?
Biological Activity
ML367 is a potent micromolar inhibitor of the ATPase family AAA domain-containing protein 5 (ATAD5). It blocks DNA repair pathways and general DNA damage responses, including UV-stimulated phosphorylation of RPA32 and phosphorylation of CHK1.
in vitro
ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd.
Western Blot Analysis
< table class="zh_use_1">Properties of N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
| storage temp. | Store at -20°C |
| solubility | DMSO: ≥ 125 mg/mL (373.89 mM) |
| form | Solid |
| color | Light yellow to yellow |
Safety information for N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
Computed Descriptors for N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
New Products
4,4-Difluoropiperidine hydrochloride tert-butyl 9-methoxy-3-azaspiro[5.5]undecane-3-carboxylate Indole Methyl Resin N-Isopropylurea N,N-Dicyclohexylcarbodiimide(DCC) MELDRUMS ACID 5-METHYLISOXAZOLE-4-CARBOXYLIC ACID Magnessium Bis glycinate Zinc ascorbate 1-bromo-2-butyne 2-acetamidophenol 9(10H)-anthracenone Erythrosin B, 4-Piperidinopiperidine 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile 2,4-dihydroxybenzaldehyde 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile Methyl 2-methylquinoline-6-carboxylate 2,6-dichloro-4-nitropyridine 4-Bromo-2-chlorobenzonitrile 2-(benzylamino)acetic acid hydrochloride 4-(tert-Butoxycarbonylamino)but- 2-ynoic acid 3,4-dihydro-2H-benzo[b][1,4]dioxepine 1-Phenyl-1-cycloprppanecarboxylicacidRelated products of tetrahydrofuran
![[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone](https://img.chemicalbook.in/CAS/20180629/GIF/1360705-96-9.gif)
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