N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
- CAS NO.：381168-77-0
- Empirical Formula: C19H12F2N4
- Molecular Weight: 334.32
- Update Date: 2026-07-27 17:00:41
What is N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine?
Biological Activity
ML367 is a potent micromolar inhibitor of the ATPase family AAA domain-containing protein 5 (ATAD5). It blocks DNA repair pathways and general DNA damage responses, including UV-stimulated phosphorylation of RPA32 and phosphorylation of CHK1.
in vitro
ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd.
Western Blot Analysis
< table class="zh_use_1">Properties of N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
| storage temp. | Store at -20°C |
| solubility | DMSO: ≥ 125 mg/mL (373.89 mM) |
| form | Solid |
| color | Light yellow to yellow |
Safety information for N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
Computed Descriptors for N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
New Products
9-Mesityl-10-methylacridinium perchlorate Sulfapyridine Fmoc-OSu (R)-(-)-2-Amino-1-propanol Cyclobutanone 5-bromo-4-fluoro-2-nitrobenzaldehyde 4 pentyn 1 ol N-Vinylformamide Phenethyl cinnamate Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Ethyl 3-phenylpropanoate β-Bromostyrene Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 Methyl trans-4-Aminocyclohexanecarboxylate Hydrochloride N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. 4-Nitrobenzotrifluoride 2-Pentyn-1-oL N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamideRelated products of tetrahydrofuran
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