N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide

Synonym(s):Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem;N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide;N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-tris(ethyloxy)benzamide, Smo Antagonist V

CAS NO.：329196-48-7
Empirical Formula: C26H26ClN3O4
Molecular Weight: 479.96
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-04 14:24:59

N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Structural

What is N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide?

The Uses of N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide

SANT-2 is an inhibitor of Smo (Hedgehog signaling pathway) and SAG.

What are the applications of Application

SANT-2 is an inhibitor of Smo (Hedgehog signaling pathway) and SAG

General Description

A nanomolar Smoothened (smo) antagonist that exhibits 2.3- and 6-fold weaker biological activity than SANT-1 (Cat. No. 559303), respectively, in antagonizing ShhNp- and SAG-stimulated hedgehog pathway activation in HEK 293-based (Shh-LIGHT2) reporter assays. Competitive binding studies show full replacement of Smo-bound cyclopamine (Cat. No. 239803) by SANT-1 and SANT-2 (K_i = 2.4 and 8.4 nM, respectively), while SANT-1 and SANT-2 are shown to compete against Smo-bound SAG-1.3 (Cat. Nos. 566660 & 566661) in an allosteric manner and that only SANT-2, but not SANT-1, is able to completely compete off bound SAG-1.3 (100% vs. 40% replacement by the respective compound at 10 μM).

Biochem/physiol Actions

SANT-2 is a potent sonic hedgehog pathway (shh) antagonist that directly inhibits by binding to the smoothened receptor.

Properties of N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide

Melting point:	210-211℃
Density	1.287±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: soluble20mg/mL, clear
form	White powder
pka	10.95±0.10(Predicted)
color	white to beige

Safety information for N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide

Computed Descriptors for N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide

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