N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea

Synonym(s):N-(2-Methyl-6-benzoxazolyl)-N′-1,5-naphthyridin-4-yl-urea;SB334867;SB-334867;SB-334867A

CAS NO.：249889-64-3
Empirical Formula: C17H13N5O2
Molecular Weight: 319.32
MDL number: MFCD06411602
EINECS: 604-604-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-09-12 18:49:14

N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea Structural

What is N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea?

The Uses of N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea

SB 334867 is an orexin-1-receptor antagonist. An important ligand for the study of the orexin 1 (OX1) receptor due to its high OX1/OX2 selectivity and bioavailability.

Definition

ChEBI: 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea is a naphthyridine derivative.

Biological Activity

Selective non-peptide orexin OX 1 receptor antagonist. pK b values are 7.2 and < 5 for inhibition of intracellular Ca 2+ release in CHO cells expressing human OX 1 and OX 2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo .

References

[1] smart d, sabido-david c, brough s j, et al. sb-334867-a: the first selective orexin-1 receptor antagonist. british journal of pharmacology, 2001, 132(6): 1179-1182.
[2] rodgers r j, halford j c g, nunes de souza r l, et al. sb-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-a in rats. european journal of neuroscience, 2001, 13(7): 1444-1452.

Properties of N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea

Melting point:	>235°C (dec.)
storage temp.	Desiccate at RT
solubility	Dichloromethane (Slightly), DMSO (Slightly)
form	Solid
color	White

Safety information for N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea

Computed Descriptors for N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea

New Products

2-Amino-5-bromo-4-(trifluoromethyl)pyridine Sulfapyridine Fmoc-OSu (R)-(-)-2-Amino-1-propanol Cyclobutanone 5-bromo-4-fluoro-2-nitrobenzaldehyde β-Bromostyrene Ethyl 3-phenylpropanoate Phenethyl cinnamate Dipropyl disulfide N-Vinylformamide 4 pentyn 1 ol Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL 2-Pentyn-1-oL 4-Nitrobenzotrifluoride N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide

Related products of tetrahydrofuran

1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride

N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA

1,5-NAPHTHYRIDIN-4-AMINE